(+)-T-Muurolol synthase (EC 4.2.3.98) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming).[1] This enzyme catalyses the following chemical reaction
| (+)-T-muurolol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.98 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnesyl diphosphate + H2O (+)-T-muurolol + diphosphate
The cyclization mechanism involves an intermediate nerolidyl diphosphate.
References
edit- ^ Hu Y, Chou WK, Hopson R, Cane DE (January 2011). "Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases". Chemistry & Biology. 18 (1): 32–7. doi:10.1016/j.chembiol.2010.11.008. PMC 3034312. PMID 21276937.
External links
edit- (+)-T-muurolol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
