Infectious pancreatic necrosis birnavirus Vp4 peptidase (EC 3.4.21.115, infectious pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
| Infectious pancreatic necrosis birnavirus Vp4 peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.115 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Cleaves the (Ser/Thr)-Xaa-Ala-(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Infectious pancreatic necrosis virus is a birnavirus that causes an acute, contagious disease in young salmonid fish.
References
edit- ^ Manning DS, Leong JC (November 1990). "Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus". Virology. 179 (1): 16–25. doi:10.1016/0042-6822(90)90268-v. PMID 2219718.
- ^ Petit S, Lejal N, Huet JC, Delmas B (March 2000). "Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus". Journal of Virology. 74 (5): 2057–66. doi:10.1128/jvi.74.5.2057-2066.2000. PMC 111686. PMID 10666235.
- ^ Dobos, P. (1995). "The molecular biology of infectious pancreatic necrosis virus (IPNV)". Annu. Rev. Fish Dis. 5: 25–54. doi:10.1016/0959-8030(95)00003-8.
External links
edit- Infectious+pancreatic+necrosis+birnavirus+Vp4+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
