User:Somogyi26/Draft part1 to Szentagothai article

Janos Szentagothai
Born	(1912-10-31)31 October 1912, Budapest, Hungary
Died	September 8, 1994(1994-09-08) (aged 81), Budapest, Hungary
Citizenship	Hungarian
Known for	Midbrain and spinal reflex arcs synaptic organization of the Lateral geniculate nucleus, cerebral and cerebellar cortices Modular organization of the cerebral and cerebellar cortices
Spouse	Biberauer Alice (1912–1996)
Awards	Kossuth-díj (in Hungarian) Állami díj I. fokozat (in Hungarian) Akadémiai Aranyérem (in Hungarian) A Magyar Köztársasági Érdemrend középkeresztje a csillaggal (in Hungarian)
Scientific career
Fields	Anatomy Endocrinology Neuroscience
Institutions	Pėter Pázmány University of Science, Budapest University of Pécs Semmelweis University, Budapest (former medical faculty of the Pėter Pázmány University of Science, Budapest)
Academic advisors	Mihály Lenhossék (1868–1937) Péter Mihálik Lajos Podhradszky
Notable students	Béla  Flerkó (in Hungarian) Bėla  Halász József  Hámori Bėla  Mess Miklós  Palkovits (in Hungarian) Miklós  Réthelyi Péter  Somogyi György  Szėkely

Janos Szentagothai (in Hungarian: Szentágothai János; 31 October 1912 – 8 September 1994; Schimert János until age 28) a prominent anatomist and neuroscientist, who was born, educated and worked in Hungary. He contributed to understanding of basic architecture of brain areas involved in reflex arcs and in neuronal control of the endocrine system. His view of the brain, as a network of cells assembling into modules, stimulated generations of neuroscientists. He left for posterity not only his ideas and discoveries, but also a flourishing school of pupils, a number of friends and admirers. Late in his life, he held posts in Hungarian public and political life. He was president of the Hungarian Academy of Sciences and member of the Hungarian National Assembly. The United Nations Educational, Scientific and Cultural Organization (UNESCO) dedicated year 2012 to his memory together with the Hungarian-British orchestral and operatic conductor Sir Georg Solti.

Early life and education

Janos Szentagothai was born to Gustav Schimert and his wife Margit Antal as the second of their six sons, in Budapest on 31 October 1912. His paternal ancestors were Transylvanian Saxons, while form his his maternal side he inherited Hungarian and Szekely blood. The history of his family records renowned physicians, back to the 17th century.

Szentágothai’s father was a man with inclination for introspection and religious pietism. He was an excellent physician with a crystal-clear mind, a unique sense of diagnostics and clinical practice, nevertheless in his daily medical activities he often resorted to homeopathic practices, despised by the representatives of the “official course of academic medicine”. “He was doubly heretic: as a physician, he was a homepath, as a religious man, he was anti-clerical and a free church leader” – noted Szentágothai. His mother, Margit Antal, was a counterpart of his husband: a down-to-earth “grand lady” with a big heart and aristocratic manners. She was rigorous, puritanical, full of irony and a deep dedication to the beauties of nature, which all her sons inherited. Of the six brothers, born between 1910 and 1918, five reached adulthood and all of them became medical doctors.

After his years in the elementary school, he attended the German Gymnasium (Reichsdeutsche Schule) in Budapest. The gymnasium had a uniquely enlightened and tolerant atmosphere. Several teachers had arrived from Germany after the collapse of the Weimar Republic, continued the spirit of German liberalism and regarded the school as their shelter. The students primarily came from upper middle class families; the language of instruction was German, but all the students had to learn Hungarian, Latin, French and English as well. After his secondary school graduation, Szentágothai started his university studies at the Medical Faculty of the Péter Pázmány University, Budapest, in 1930, and graduated as a medical doctor in 1936. In 1938 he married to Alice Biberauer and the couple had three daughters, Katalin (1939), Klára (1941) and Mária Krisztina (1951). In 1940, he changed his original family name “Schimert” to Szentágothai, as a reference to the place of origin of his father’s family. The village Szentágota (Agnetheln in German, Agnita in Rumanian) belonged to the Transylvanian Saxon community and is 60 km from their former main town, Nagyszeben (Hermannstadt, Sibiu). Some of the forefathers of Szentágothai owned an estate in the village, and one of his great-uncles, Count Kálmán Lang de Szentágotha was the landlord.

Scientific career

University Demonstrator in Anatomy, Budapest Medical School 1936-44; Professor of Anatomy, Pecs University 1946-63; Professor of Anatomy, Semmelweis University, Budapest 1963-77; President, Hungarian Academy of Sciences 1977-85; Emeritus Professor and Head of the Neurobiology Group, Semmelweis Medical School 1986-94; Member, Hungarian Parliament 1985-94; married 1938 Alice Biberauer (three daughters); died Budapest 8 September 1994.

He was born Janos Schimert, in Budapest in 1912, to Dr Gustav Schimert and Margit Antal, into a well-to-do medical family. With his five brothers he received a strict and privileged upbringing (he liked to boast about their Swiss nurse) which was apparent in his aristocratic manners and broad artistic and literary knowledge. At the age of 16 he received a small microscope as a Christmas present and within a few months managed to produce some hand-cut histological sections from the brain of an unfortunate mouse he caught, which he stained with the Golgi method, revealing individual nerve cells in all their beauty. As he put it, what he saw resulted in 'a love at first sight' and the 'imprinting experience' engaged him with the brain for a lifetime. Some of his later discoveries, particularly in the neocortex and cerebellum, were produced by the same Golgi method (introduced by Camillo Golgi, an Italian histologist at the end of the last century) which is used to this day for visualising nerve cells. The same method was extensively used by Ramon y Cajal, one of the greatest neuroscientists of all time.

Schimert started his medical studies at the Budapest University Medical School in 1930, and was accepted in the first year by Professor Michael von Lenhossek as a research student in the Department of Anatomy. This was a most stimulating and creative place for basic research, for Hungary wanted to show the world her intellectual powers after the great 'Carthagesque' tragedy that befell the Magyar people at the end of the First World War. As a student he described essentially correctly in his first light microscopic papers, published in German (1936- 39), the termination of vegetative peripheral nerves, 20 years before electron microscopes were invented. He applied the silver impregnation that he used for peripheral nerves to the lesioned nerves in the central nervous system, pioneering the tracing of links between pathways in the brain and spinal cord. He received his MD in 1936 and continued to teach at Budapest, becoming Associate Professor in 1942.

He changed his name from Schimert to Szentagothai (after a Magyar ancestor) as a protest against the Nazi occupation. In publications in English he signed himself John Szentagothai. The years of the Second World War were disruptive to progress, but no sooner had the dust settled in the war-ravaged country than Szentagothai was back from an American POW camp in the southern city of Pecs early in 1946 and, at the age of 34, took the Chair of Anatomy of a department whose staff had all left as a result of the war. He surrounded himself with gifted students, creating a research atmosphere where originality and discovery flourished; four of his students from the Pecs days became internationally acclaimed pioneers themselves and heads of anatomy departments in different medical schools in Hungary. Using his silver stain and ingenuity Szentagothai provided unequivocal anatomical proof for the monosynaptic bi-neuronal reflex arc of the stretch reflex. With Gyorgy Szekely he transplanted eyes and limbs of newts to reveal how nerves regenerate to innervate them and in the process recognised the principle of neuronal self-organisation. With Bela Halasz, Bela Flerko and Bela Mess he discovered how the hypothalamic area of the brain governs the secretion of hormones from the pituitary gland which in turn govern our growth, sexual physiology, and response to stress.

The kind of anatomy Szentagothai pioneered was functional indeed (later he wrote a textbook, Functional Anatomy, widely used in Hungary today). This is well illustrated by his discoveries in the extraordinary experiments he conducted on how the brain keeps the eyes steady on target while the body and the head move in three dimensions. In a series of experiments from 1946 with Andras Gomori's team he established the direct tri-neural pathway, the gyroscope of the brain, from the semicircular canals of the inner ear to the extraocular muscles that change the position of the eye (published in 1952 in a monograph in German).

In1938 he married Alice Biberauer, a women of exceptional warmth and kindness, who kept a close watch over his demanding schedule, trying to buffer the many conflicting interests draining his energy. In the later years she was a constant and cheerful companion at international meetings. Their three daughters all took up medical careers.

In 1963 he moved to the Chair of Anatomy at the Semmelweis Medical School in Budapest, where he had studied as a student 30 years earlier. Again, he created a department of world repute. In Budapest, working with Jozsef Hamori, he concentrated on the organisation of the cerebellar neuronal network and renewed a collaboration and a lifelong friendship with Sir John Eccles. Their book, published with Masao Ito from the heroic studies of the Sixties, The Cerebellum as a Neuronal Machine (1967), became a classic in the history of neuroscience. Szentagothai's recognition of the basis of lateral inhibition in the cerebellar cortex - which 'came as a flash' to him during one of his undergraduate lectures, remains a basic concept of cerebellar organisation. Also in the Sixties he discovered the principle of glomerular synapses, first in the thalamus later in the cerebellum.

Since he was a romantic visionary rather than an analytical scientist Szentagothai could generalise his findings without inhibition with an enchanting elegance. One such generalisation, the concept of the modular organisation of neural centres, can be followed through his studies in the Fifties and Sixties and was elaborated in the 1974 volume of the Neuroscience Research Programme Bulletin, published with M. A. Arbib; the copy in the Radcliffe Science Library at Oxford was read into shreds years ago. This concept, applied to the cerebral cortex, formed the theme of his Ferrier Lecture to the Royal Society in 1977. Entangling the neuronal network of the cortex, the seat of all of our conscious experience and achievements, remained his last important scientific adventure: a field, as so many others, where he leaves behind a school of thought that will continue to draw from his vision.

In the last two decades of his life, as a religious man, he grappled with the scientific and philosophical problems of the brain- mind-psyche relationship, concluding in his paper 'Too much and too soon', published in 1982 in English in Hungary: 'no speculation can remove our responsibility for our actions and behaviour'. He was deeply concerned with, and actively worked to avoid, the 'abyss of an atomic holocaust' as well as the destruction of the natural environment.

As his fame increased so did the expectations of administrative duties and he rose in the ranks of the Hungarian Academy of Sciences, being elected President in 1977 and again in 1980 until 1985. This was an arduous task requiring compromises in the interest of maintaining the academy's scientific mission, as he had to report to one of the most powerful members of the Politburo, the Deputy Prime Minister Gyorgy Aczel, a Communist ruler par excellence. In 'Too much and too soon' Szentagothai notes 'It is the ultimate joke of fate . . . that it should befall someone originating from an upper middle-class background, of unorthodox philosophy, and an utterly cynical - albeit compassionate - observer of the whole 'vanity fair' of this world to become the President of an 'Eastern-type socialist' academy. However, I try to serve my country to the best of my abilities.' As a teacher Szentagothai greatly influenced three generations of doctors and scientists, his magnetism attracting talent, and today various of his pupils lead brain research world-wide.

It is not accidental that, as measured by research publications in relation to its population or its gross domestic product, Hungary is among the first countries in the world in her impact on neuroscience research. Szentagothai's Atlas Anatomiae Corporis Humani, published with Professor Ferenc Kiss, has seen more than 82 editions and been translated into at least 13 languages including Chinese and Slovenian. He designed and drew much of the artwork for this fundamental book. He enjoyed painting and his papers are full of imaginative three-dimensional illustrations of his vision of the neuronal circuits.

In spite of his administrative duties, the many international obligations (he was equally acclaimed in the West as in the then Eastern Bloc), the lectures to the medical students (he lectured in German, French and English) that he would try to give above all other demands, his office was always open to us young scientists, who used to queue up to show our results in the hope of gaining from his criticism. And critical he was; his roaring baritone could be heard echoing in the corridors, but the discussion were infectious and his genius provided food for thought which made the place such a stimulating environment.

He liked to impress the young scientists with an image of a 'street fighter', often joking about how much he was favoured by fate by not dying of the sepsis that he got in a dissection, or at the time when as a POW in the Second World War a drunken GI pressed his loaded machine-gun to his ribs, or of the high blood pressure that he had to cope with for the last 40 years of his life, or in the heart attack that inevitably followed from the punishing schedule of administrative duties, scientific and public commitments. But he was essentially a gentle, often timid and self-doubting person, who would try to avoid conflict at all cost.

In his later years he often warned us against the 'ugly competitiveness that appeared in the field' and reminisced about the days when science was a 'gentlemanly pursuit', not a road to power and wealth. However, when the time came he stood up for his staff, friends and colleagues, irrespective of their importance. He would not hesitate to write to, phone up and harass those in power in order to help the less fortunate. On one occasion, when a young scientist needed a piece of equipment, costing dollars 1,200 and unobtainable in Hungary, he simply bought it from his publisher's royalty (equivalent to six months of his full salary) on one of his conference trips and put it on the astonished scientist's desk.

When the Soviet empire crumbled in 1989-90, Szentagothai, aged 78 and with a pacemaker that he often cursed for not allowing his heart to pump enough blood at times of high emotional involvement, again chose to do his best for his country's rebirth, serving as an MP in the colours of the governing Democratic Forum in the first democratically elected parliament. His televised parliamentary speeches, liberally spiced with Latin, Greek and literary quotations, bemused his fellow MPs and television audiences. In the turmoil of the scramble for power his voice was always a refreshing spell of humanity and caring for the future of his people.

Szentagothai lived through and influenced the turbulent history of a country that history has not favoured. He managed to maintain a creative contribution under the darkest of historic circumstances not only to his country's culture and education, but to the pool of Man's universal knowledge. In his recent witty biographical self-

portrait As a Ulysses around the Brain (1994), written as a monologue and applying James Joyce's Ulysses and Thomas Mann's Lotte in Weimar to his life, he professed that the aims of his life had been, 'to be a good neuroscientist, to remain cultural in the sense of the end of the 20th century, to remain an honourable man under the historic circumstances and above all, to remain a good Christian'. Those who knew him well bear witness to how wonderfully he succeeded in these ambitions

After WWII, his results stirred international interest from 1946: Szentágothai provided evidence for the existence of inhibitory neurons, and greatly contributed to the mapping of the neural network of the cerebellum. As a reward for his achievements, he was elected a corresponding member of the Academy at the very young age of 36 in 1948. One of the highlights of his career was the publication of an English-language monograph summarising the results of a decade-long research, with co-authors Béla Flerkó, Béla Mess and Béla Halász. The study described the neural regulation of the workings of the trop hormone. His scientific stance was best described in the writings of his successor at the Institute of Anatomy in Pécs, Béla Flerkó. He did not believe that science is the mere accumulation of facts, and that a researcher is just a collector of facts, Flerkó wrote. Instead, he firmly believed: a researcher may spend a lifetime collecting and recording all available information about his or her research topic, yet he or she won't have anything to show for his/her efforts without a solid concept of research. Szentágothai always worked by following research concepts, and if he could not confirm them with experimental results, he immediately disregarded them and adopted new ones. -->

He articulated the principle of relativity. This was understood by Hermann Minkowski to be a generalization of rotational invariance from space to space-time. Other principles postulated by Einstein and later vindicated are the principle of equivalence and the principle of adiabatic invariance of the quantum number.

Political and religious views

Main articles: Albert Einstein's political views and Albert Einstein's religious views

Albert Einstein, seen here with his wife Elsa Einstein and Zionist leaders, including future President of Israel Chaim Weizmann, his wife Dr. Vera Weizmann, Menahem Ussishkin, and Ben-Zion Mossinson on arrival in New York City in 1921.

Albert Einstein's political view was in favor of socialism; his political views emerged publicly in the middle of the 20th century due to his fame and reputation for genius. Einstein offered to and was called on to give judgments and opinions on matters often unrelated to theoretical physics or mathematics.

Einstein's views about religious belief have been collected from interviews and original writings. These views covered Judaism, theological determinism, agnosticism, and humanism. He also wrote much about ethical culture, opting for Spinoza's god over belief in a personal god.

1956-ban a pécsi Értelmiségi Forradalmi Bizottság elnöke volt. A közéletbe majd csak 1973-ben tért vissza, amikor a Magyar Tudományos Akadémia alelnökévé választották. Négy évvel később a tudományos köztestület elnöke lett, emiatt távozott tanszékvezetői pozíciójáról. 1985-ben távozott onnan, amikor országgyűlési képviselő és a Magyar Népköztársaság Elnöki Tanácsának tagja lett (utóbbinak annak megszüntetéséig tagja volt).

A rendszerváltás során bekapcsolódott a Magyar Demokrata Fórum munkájába. Az 1990-es országgyűlési választáson már a rendszerváltó párt színeiben, annak országos listájáról szerzett mandátumot. A külügyi bizottság tagjaként dolgozott. A ciklus lejárta után pár hónappal hunyt el.

1985-tõl országgyûlési képviselõ, a külügyi bizottságnak és 1989-ig az Elnöki Tanácsnak tagja. 1989-90 a tudománypolitikai és mûszaki fejlesztési bizottság tagja. 1990-tõl a Magyar Demokrata Fórum országgyûlési képviselõje. A Tudományos Ismeretterjesztõ Társulat elnöke, az Interparlamentáris Unió (IPU) magyar csoportjának végrehajtó bizottsági tagja, a Páneurópai Unió magyar egyesületi elnökségi tagja. Széleskörû érdeklõdésével a Magyar Bibliofil Társaság elnöke, 1987-tõl a Magyar-Osztrák Baráti Körnek, 1990-tõl a Magyar Természettudományi Társulatnak elnöke.

Positions held

• 1932-1936: Student demonstrator
• 1936-1946: Instructor, assistant professor, associate professor, Department of Anatomy, Péter Pázmány University, Faculty of Medicine, Budapest
• 1946-1963: Professor and Chair, Department of Anatomy, University Medical School of Pécs
• 1963-1986: Professor, Department of Anatomy, University Medical School of Budapest
• 1963-1977: Head, Department of Anatomy, University Medical School of Budapest
• 1973-1977: Vice President of the Hungarian Academy of Sciences
• 1977-1985: President of the Hungarian Academy of Sciences
• 1985-1994: Past President and Professor Emeritus, Hungarian Academy of Sciences

Honors and awards

Decorations

• 1950 and 1978 : Kossuth Award, Hungary
• 1970: State Prize, Hungary
• 1985: Golden Medal of the Hungarian Academy of Sciences
• 1992: Order of Merit of the Hungarian Republic (Commander with Star)

Honorary degrees

• University of Oxford
• University of Turku
• University of Pécs

Awards

• 1984: F.O.Schmitt Prize of Neuroscience

Professional organizations

• 1976-1978: President, European Neuroscience Association
• 1966-1976: member, editorial board, Experimental Brain Research
• 1972-1980: member, editorial board, The Journal of Comparative Neurology
• 1966-1978: member, editorial board, Brain Research
• 1991-1994: member, advisory board, Cerebral Cortex

International lectureships

• 1977: Ferrier Lecture

Membership in learned societies and professional bodies

• Hungarian Academy of Sciences,
• Foreign Memberof the Royal Society (1978)
• National Academy of Sciences USA
• Leopoldina German Academy of Naturalists
• Academy of Sciences of the USSR
• American Academy of Arts and Sciences (Boston)
• Finnish Academy of Sciences
• Mainz Academy of Sciences
• Pontifical Academy of Sciences
• Royal Belgian Academy of Medicine
• Royal Norwegian Academy
• Royal Swedish Academy of Sciences
• Serbian Academy of Sciences

External links

• Ulyssesként az agy körül (in Hungarian)
• Magyarország a XX. században – Neurobiológia (in Hungarian)