Paragonimus kellicotti, the North American lung fluke, is a species of parasitic trematode in the genus Paragonimus. This species of Paragonimus has an intricate lifecycle, and although its name may suggest that it is only a health concern in North America, it is also prominent in Southeast Asia and China.
| Paragonimus kellicotti | |
|---|---|
Scientific classification 
| |
| Domain: | Eukaryota |
| Kingdom: | Animalia |
| Phylum: | Platyhelminthes |
| Class: | Trematoda |
| Order: | Plagiorchiida |
| Family: | Paragonimidae |
| Genus: | Paragonimus |
| Species: | P. kellicotti
|
| Binomial name | |
| Paragonimus kellicotti Ward, 1908
| |
Morphology
editParagonimus kellicotti parasites have dorsoventrally flattened, brown, oval-shaped bodies. They are soft-bodied parasites with oral and ventral suckers that are relatively similar in size. They use their ventral suckers to attach to a host. Their tegument is covered with spines, which is a characteristic that sets them apart among other Paragonimus species. Lung flukes are hermaphroditic, having both the female and male organs. Thus, they are able to self-fertilize.[1]
Habitat
editEarly larval stages are found in snails and later move on to crustaceans, primarily crawfish and crabs. P. kellicotti parasites may live in fresh or salt water. Thus, they may be found within hosts of swamp, coastal, or forest areas.
Development
editLung fluke eggs are passed through feces or soil. Eggs then hatch into miricidia within three weeks. A miricidium infects the primary host, snails. Within snails, the miricidium develops into a cercaria. The cercariae eventually leave the snail and infect the second intermediate host, crustaceans. The lung fluke encysts within the tissue of crustaceans until the crustacean is consumed by humans or other animals. Once the fluke has been ingested, enzymes within the digestive tract of the consumer break down the parasitic cysts. The immature parasite continues to mature within the lungs of its new host, feeding on its intestine, and lay eggs. Mature lung flukes may breed year-round. P. kellicotti may live up to 20 years within a human host.
Infection
editInfections of P. kellicotti affect 21 million people worldwide. However, humans rarely become infected in North America. The frequent victims of this infection in North America are small animals that feed on crayfish, such as otters, skunks, and mink. Occasionally, dogs and cats become infected, as well. If these animals are left without treatment, they eventually die. P. kellicotti is a food-borne trematode infection. Humans become infected with the parasite by eating raw or undercooked crayfish meat that contains the parasite larvae. These infections are common in sub-Saharan Africa. After the parasite has been ingested, it will travel from the intestines until it reaches the lungs.
Signs of infection
editSeveral diagnostic signs indicate a lung fluke infection. These include a cough, fever, and weight loss.[2] Pleural effusion, a condition in which a surplus of fluid accumulates around the lungs, is another sign of an infection. P. kellicotti infection may sometimes be misdiagnosed as tuberculosis. However, a lung fluke infection is differentiated from tuberculosis by increased eosinophils in the blood and pleural fluid.
Treatment
editA P. kellicottii treatment in humans consists oral medication of praziquantel over a minimum of three days to achieve a 100% cure rate [3] when the parasite is located in the lungs. Other ectopic infections may require surgical removal. Surgery does not guarantee all larvae will be removed.
References
edit- ^ "Animal Diversity Web." ADW: Paragonimus Kellicotti: INFORMATION. N.p., n.d. Web. 27 Oct. 2013.
- ^ Baum, Stephen G. "Paragonimiasis -- Cook Those Crawdads!" Journal Watch. Infectious Diseases (2010): n. pag. ProQuest. Web. 12 Oct. 2013.
- ^ Procop, Gary W. (July 2009). "North American Paragonimiasis (Caused by Paragonimus kellicotti) in the Context of Global Paragonimiasis". Clin Microbiol Rev. 22 (3): 415–446. doi:10.1128/CMR.00005-08. PMC 2708389. PMID 19597007.
- Fischer, Peter U.; Curtis, Kurt C.; Marcos, Luis A.; Weil, Gary J. (June 2011). "Molecular characterization of the North American lung fluke Paragonimus kellicotti in Missouri and its development in Mongolian gerbils". Am J Trop Med Hyg. 84 (6): 1005–11. doi:10.4269/ajtmh.2011.11-0027. PMC 3110363. PMID 21633042.
- Lane MA, Barsanti MC, Santos CA, Yeung M, Lubner SJ, Weil GJ (2009). "Human paragonimiasis in North America following ingestion of raw crayfish". Clin Infect Dis. 49 (6): e55–61. doi:10.1086/605534. PMID 19681705.
- Lane MA, Marcos LA, Onen NF, Demertzis LM, Hayes EV, Davila SZ, Nurutdinova DR, Bailey TC, Weil GJ (August 2012). "Paragonimus kellicotti flukes in Missouri, USA". Emerg Infect Dis. 18 (8): 1263–7. doi:10.3201/eid1808.120335. PMC 3414046. PMID 22840191.