SLC22A2

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2) is a protein that in humans is encoded by the SLC22A2 gene.

SLC22A2
Identifiers
Aliases	SLC22A2, OCT2, solute carrier family 22 member 2
External IDs	OMIM: 602608; MGI: 1335072; HomoloGene: 68293; GeneCards: SLC22A2; OMA:SLC22A2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q25.3 Start 160,171,061 bp End 160,277,638 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A1|17 8.61 cM Start 12,803,019 bp End 12,847,375 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule renal medulla human kidney testicle glomerulus metanephric glomerulus buccal mucosa cell oocyte secondary oocyte right coronary artery Top expressed in right kidney proximal tubule human kidney yolk sac proximal convoluted tubule proximal straight tubule respiratory epithelium olfactory epithelium sciatic nerve embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter activity transporter activity neurotransmitter transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transmembrane transporter activity acetylcholine transmembrane transporter activity norepinephrine:sodium symporter activity secondary active organic cation transmembrane transporter activity organic anion transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane extracellular exosome integral component of plasma membrane presynapse Biological process xenobiotic transmembrane transport body fluid secretion quaternary ammonium group transport neurotransmitter biosynthetic process cation transport ion transport dopamine transport neurotransmitter secretion organic cation transport transmembrane transport ammonium transmembrane transport neurotransmitter transport organic anion transport norepinephrine transport acetate ester transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6582 20518 Ensembl ENSG00000112499 ENSMUSG00000040966 UniProt O15244 O70577 RefSeq (mRNA) NM_153191 NM_003058 NM_013667 NM_001355767 RefSeq (protein) NP_003049 NP_038695 NP_001342696 Location (UCSC) Chr 6: 160.17 – 160.28 Mb Chr 17: 12.8 – 12.85 Mb PubMed search
Wikidata
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Poly specific organic cation transporters in the liver, kidney, intestine, and other organs are important for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.

See also

• Solute carrier family

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. doi:10.1128/JVI.66.1.139-149.1992. PMC 238269. PMID 1727476.
• Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. doi:10.1128/JVI.67.10.6224-6233.1993. PMC 238044. PMID 7690421.
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060. S2CID 11659500.
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 (1): 155–8. doi:10.1042/bj3220155. PMC 1218171. PMID 9078256.
• Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930.
• Busch AE, Karbach U, Miska D, et al. (1998). "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". Mol. Pharmacol. 54 (2): 342–52. doi:10.1124/mol.54.2.342. PMID 9687576.
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
• Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". Hum. Genet. 106 (6): 627–35. doi:10.1007/s004390050035. PMID 10942111.
• Pietig G, Mehrens T, Hirsch JR, et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.
• Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152. PMID 11483518.
• Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. Biol. Chem. 277 (25): 22491–6. doi:10.1074/jbc.M203114200. PMID 11953440.
• Urakami Y, Akazawa M, Saito H, et al. (2002). "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". J. Am. Soc. Nephrol. 13 (7): 1703–10. doi:10.1097/01.ASN.0000019413.78751.46. PMID 12089365.
• Leabman MK, Huang CC, Kawamoto M, et al. (2003). "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Pharmacogenetics. 12 (5): 395–405. doi:10.1097/00008571-200207000-00007. PMID 12142729.
• Cetinkaya I, Ciarimboli G, Yalçinkaya G, et al. (2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. doi:10.1152/ajprenal.00251.2002. PMID 12388397. S2CID 38608510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837. S2CID 11496882.
• Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
• Lips KS, Volk C, Schmitt BM, et al. (2005). "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. CiteSeerX 10.1.1.327.6767. doi:10.1165/rcmb.2004-0363OC. PMID 15817714.
• Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMC 1190334. PMID 16024787.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.