Mazzarino may refer ro:
- Mazzarino, Sicily, a city and commune in Sicily, Italy
- Mazzarino Friars, a criminal group of Capuchin friars active in Mazzarino in the 1950s and 60s
- Joey Mazzarino (born 1968), American puppeteer and actor
- Giulio Raimondo Mazzarino (1602–1661), Italian cardinal
- Michele Mazzarino (1605–1648), Italian cardinal
- Nicolás Mazzarino (born 1975), Uruguyan basketball player
- Santo Mazzarino (1916–1987), Italian historian
This disambiguation page lists articles associated with the title Mazzarino.
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