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File:Fibrolamellar hepatocellular carcinoma -2- intermed mag.jpg

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Summary

Description
English: Intermediate magnification micrograph of fibrolamellar hepatocellular carcinoma, abbreviated FL-HCC and FHCC. H&E stain.

Features of FL-HCC:

  • Rare variant of hepatocellular carcinoma (HCC).
  • Classifically afflicits younger patients.
    • Mean age at onset ~27 years in one study.[1]
  • Individuals usually don't have the classic risk factors for HCC, i.e. no cirrhosis, no hepatitis.[1]
  • AFP usually not elevated.[1]

Microscopic features:

  • Large polygonal tumours cells with:
    • Graunular eosinophilic cytoplasm.
    • Low NC ratio.
  • Layered dense collagen bundles.
  • Low mag.
    Low mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.

References

  1. ↑ a b c (Mar 2006). "Outcome of patients with fibrolamellar hepatocellular carcinoma.". Cancer 106 (6): 1331-8. DOI:10.1002/cncr.21703.
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Author Nephron

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current20:13, 27 December 2011Thumbnail for version as of 20:13, 27 December 20114,272 × 2,848 (5.94 MB)Nephron{{Information |Description ={{en|1=Intermediate magnification micrograph of '''fibrolamellar hepatocellular carcinoma''', abbreviated '''FL-HCC''' and '''FHCC'''. H&E stain.

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