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The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.[5]
| egf-like module containing, mucin-like, hormone receptor-like 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EMR1 | ||||||
| Alt. symbols | TM7LN3 | ||||||
| IUPHAR | 182 | ||||||
| NCBI gene | 2015 | ||||||
| HGNC | 3336 | ||||||
| OMIM | 600493 | ||||||
| RefSeq | NM_001974 | ||||||
| UniProt | Q14246 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
| egf-like module containing, mucin-like, hormone receptor-like 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EMR2 | ||||||
| IUPHAR | 183 | ||||||
| NCBI gene | 30817 | ||||||
| HGNC | 3337 | ||||||
| OMIM | 606100 | ||||||
| RefSeq | NM_152916 | ||||||
| UniProt | Q9UHX3 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.1 | ||||||
| |||||||
| egf-like module containing, mucin-like, hormone receptor-like 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EMR3 | ||||||
| IUPHAR | 184 | ||||||
| NCBI gene | 84658 | ||||||
| HGNC | 23647 | ||||||
| OMIM | 606101 | ||||||
| RefSeq | NM_032571 | ||||||
| UniProt | Q9BY15 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.1 | ||||||
| |||||||
| egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EMR4P | ||||||
| Alt. symbols | GPR127 | ||||||
| NCBI gene | 326342 | ||||||
| HGNC | 19240 | ||||||
| RefSeq | XM_940358 | ||||||
| UniProt | Q86SQ3 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
References
edit- ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
- ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.
- ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
- ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. doi:10.1080/10425170500355737. PMID 16753812. S2CID 11216477.
- ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics. 55 (10): 655–66. doi:10.1007/s00251-003-0625-2. PMID 14647991. S2CID 28689160.
External links
edit- EMR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EMR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EMR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EMR4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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