Ubiquitin carboxyl-terminal hydrolase L5

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.

UCHL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP
Identifiers
Aliases	UCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
External IDs	OMIM: 610667; MGI: 1914848; HomoloGene: 9326; GeneCards: UCHL5; OMA:UCHL5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.2 Start 193,012,250 bp End 193,060,080 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 F|1 62.54 cM Start 143,653,010 bp End 143,683,204 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans body of pancreas prefrontal cortex muscle of thigh rectum monocyte gonad gastrocnemius muscle epithelium of colon Top expressed in morula embryo blastocyst yolk sac parotid gland otic placode tail of embryo medial vestibular nucleus deep cerebellar nuclei epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity thiol-dependent deubiquitinase peptidase activity protein binding endopeptidase inhibitor activity hydrolase activity RNA binding proteasome binding Cellular component cytoplasm intracellular anatomical structure proteasome complex nucleus cytosolic proteasome complex nucleoplasm mitochondrion cytosol Ino80 complex Biological process regulation of proteasomal protein catabolic process DNA recombination regulation of transcription, DNA-templated lateral ventricle development ubiquitin-dependent protein catabolic process transcription, DNA-templated proteolysis cellular response to DNA damage stimulus forebrain morphogenesis DNA repair midbrain development negative regulation of endopeptidase activity protein deubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51377 56207 Ensembl ENSG00000116750 ENSMUSG00000018189 UniProt Q9Y5K5 Q5LJB0 Q9WUP7 RefSeq (mRNA) NM_001199261 NM_001199262 NM_001199263 NM_015984 NM_001350840 NM_001350841 NM_001350842 NM_001350843 NM_001350844 NM_001350845 NM_001350846 NM_001350847 NM_001350848 NM_001350849 NM_001350850 NM_001350851 NM_001350852 NM_001159866 NM_019562 RefSeq (protein) NP_001186190 NP_001186191 NP_001186192 NP_057068 NP_001337769 NP_001337770 NP_001337771 NP_001337772 NP_001337773 NP_001337774 NP_001337775 NP_001337776 NP_001337777 NP_001337778 NP_001337779 NP_001337780 NP_001337781 NP_001153338 NP_062508 Location (UCSC) Chr 1: 193.01 – 193.06 Mb Chr 1: 143.65 – 143.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37". FEBS Lett. 488 (3): 201–5. doi:10.1016/S0014-5793(00)02436-4. hdl:10536/DRO/DU:30009147. PMID 11163772. S2CID 40717095.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
• Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559. S2CID 1446423.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146. S2CID 25308728.
• Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMC 1589993. PMID 16990800.
• Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMC 1698896. PMID 17139257.