Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I[5][6] is an enzyme that in humans is encoded by the PACSIN1 gene.[7]
Interactions
editPACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).
A variety of interactions have been published:
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000124507 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040276 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
- ^ "Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
- ^ Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
- ^ Qualmann B, Roos J, DiGregorio PJ, Kelly RB (February 1999). Pfeffer SR (ed.). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–513. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
- ^ Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
- ^ a b c Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
- ^ Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
- ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Further reading
edit- Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G (Apr 2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". Journal of Molecular Biology. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
- Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, et al. (Jul 2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton". The Journal of Biological Chemistry. 276 (28): 26622–8. doi:10.1074/jbc.M100591200. PMID 11352907.
External links
edit- PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)
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