Wikipedia

Personalized medicine

(Redirected from Stratified medicine)

Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease.[1] The terms personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably to describe this concept,[1][2] though some authors and organizations differentiate between these expressions based on particular nuances.[2] P4 is short for "predictive, preventive, personalized and participatory".[2]

While the tailoring of treatment to patients dates back at least to the time of Hippocrates,[3] the usage of the term has risen in recent years thanks to the development of new diagnostic and informatics approaches that provide an understanding of the molecular basis of disease, particularly genomics. This provides a clear biomarker on which to stratify related patients.[1][4][5]

Among the 14 Grand Challenges for Engineering, an initiative sponsored by National Academy of Engineering (NAE), personalized medicine has been identified as a key and prospective approach to "achieve optimal individual health decisions", therefore overcoming the challenge to "engineer better medicines".[6][7]

Development of concept

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In personalised medicine, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the patient's genetics or their other molecular or cellular characteristics.[citation needed] The use of genetic information has played a major role in certain aspects of personalized medicine (e.g. pharmacogenomics), and the term was first coined in the context of genetics, though it has since broadened to encompass all sorts of personalization measures,[8] including the use of proteomics,[9] imaging analysis, nanoparticle-based theranostics,[10] among others.

Difference between precision medicine and personalized medicine

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Precision medicine is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to a subgroup of patients, instead of a one‐drug‐fits‐all model.[11][12] In precision medicine, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient's genetic content or other molecular or cellular analysis.[13] Tools employed in precision medicine can include molecular diagnostics, imaging, and analytics.[12][14]

Precision medicine and personalized medicine (also individualized medicine) are analogous, applying a person's genetic profile to guide clinical decisions about the prevention, diagnosis, and treatment of a disease.[15] Personalized medicine is established on discoveries from the Human Genome Project.[15]

In explaining the distinction from the similar term of personalized medicine, the United States President's Council of Advisors on Science and Technology writes:[16]

Precision medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient, but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease, in the biology or prognosis of those diseases they may develop, or in their response to a specific treatment. Preventive or therapeutic interventions can then be concentrated on those who will benefit, sparing expense and side effects for those who will not.[16]

The use of the term "precision medicine" can extend beyond treatment selection to also cover creating unique medical products for particular individuals—for example, "...patient-specific tissue or organs to tailor treatments for different people."[17] Hence, the term in practice has so much overlap with "personalized medicine" that they are often used interchangeably, even though the latter is sometimes misterpreted as involving a unique treatment for each individual.[18]

Background

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Basics

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Every person has a unique variation of the human genome.[19] Although most of the variation between individuals has no effect on health, an individual's health stems from genetic variation with behaviors and influences from the environment.[20][21]

Modern advances in personalized medicine rely on technology that confirms a patient's fundamental biology, DNA, RNA, or protein, which ultimately leads to confirming disease. For example, personalised techniques such as genome sequencing can reveal mutations in DNA that influence diseases ranging from cystic fibrosis to cancer. Another method, called RNA-seq, can show which RNA molecules are involved with specific diseases. Unlike DNA, levels of RNA can change in response to the environment. Therefore, sequencing RNA can provide a broader understanding of a person's state of health. Recent studies have linked genetic differences between individuals to RNA expression,[22] translation,[23] and protein levels.[24]

The concepts of personalised medicine can be applied to new and transformative approaches to health care. Personalised health care is based on the dynamics of systems biology and uses predictive tools to evaluate health risks and to design personalised health plans to help patients mitigate risks, prevent disease and to treat it with precision when it occurs. The concepts of personalised health care are receiving increasing acceptance with the Veterans Administration committing to personalised, proactive patient driven care for all veterans.[25] In some instances personalised health care can be tailored to the markup of the disease causing agent instead of the patient's genetic markup; examples are drug resistant bacteria or viruses.[26]

Precision medicine often involves the application of panomic analysis and systems biology to analyze the cause of an individual patient's disease at the molecular level and then to utilize targeted treatments (possibly in combination) to address that individual patient's disease process. The patient's response is then tracked as closely as possible, often using surrogate measures such as tumor load (versus true outcomes, such as five-year survival rate), and the treatment finely adapted to the patient's response.[27][28] The branch of precision medicine that addresses cancer is referred to as "precision oncology".[29][30] The field of precision medicine that is related to psychiatric disorders and mental health is called "precision psychiatry."[31][32]

Inter-personal difference of molecular pathology is diverse, so as inter-personal difference in the exposome, which influence disease processes through the interactome within the tissue microenvironment, differentially from person to person. As the theoretical basis of precision medicine, the "unique disease principle"[33] emerged to embrace the ubiquitous phenomenon of heterogeneity of disease etiology and pathogenesis. The unique disease principle was first described in neoplastic diseases as the unique tumor principle.[34] As the exposome is a common concept of epidemiology, precision medicine is intertwined with molecular pathological epidemiology, which is capable of identifying potential biomarkers for precision medicine.[35]

Method

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In order for physicians to know if a mutation is connected to a certain disease, researchers often do a study called a "genome-wide association study" (GWAS). A GWAS study will look at one disease, and then sequence the genome of many patients with that particular disease to look for shared mutations in the genome. Mutations that are determined to be related to a disease by a GWAS study can then be used to diagnose that disease in future patients, by looking at their genome sequence to find that same mutation. The first GWAS, conducted in 2005, studied patients with age-related macular degeneration (ARMD).[36] It found two different mutations, each containing only a variation in only one nucleotide (called single nucleotide polymorphisms, or SNPs), which were associated with ARMD. GWAS studies like this have been very successful in identifying common genetic variations associated with diseases. As of early 2014, over 1,300 GWAS studies have been completed.[37]

Disease risk assessment

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Multiple genes collectively influence the likelihood of developing many common and complex diseases.[20] Personalised medicine can also be used to predict a person's risk for a particular disease, based on one or even several genes. This approach uses the same sequencing technology to focus on the evaluation of disease risk, allowing the physician to initiate preventive treatment before the disease presents itself in their patient. For example, if it is found that a DNA mutation increases a person's risk of developing Type 2 Diabetes, this individual can begin lifestyle changes that will lessen their chances of developing Type 2 Diabetes later in life.[citation needed]

Practice

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The ability to provide precision medicine to patients in routine clinical settings depends on the availability of molecular profiling tests, e.g. individual germline DNA sequencing.[38] While precision medicine currently individualizes treatment mainly on the basis of genomic tests (e.g. Oncotype DX[39]), several promising technology modalities are being developed, from techniques combining spectrometry and computational power to real-time imaging of drug effects in the body.[40] Many different aspects of precision medicine are tested in research settings (e.g., proteome, microbiome), but in routine practice not all available inputs are used. The ability to practice precision medicine is also dependent on the knowledge bases available to assist clinicians in taking action based on test results.[41][42][43] Early studies applying omics-based precision medicine to cohorts of individuals with undiagnosed disease has yielded a diagnosis rate ~35% with ~1 in 5 of newly diagnosed receiving recommendations regarding changes in therapy.[44] It has been suggested that until pharmacogenetics becomes further developed and able to predict individual treatment responses, the N-of-1 trials are the best method of identifying patients responding to treatments.[45][46]

On the treatment side, PM can involve the use of customized medical products such drug cocktails produced by pharmacy compounding[47] or customized devices.[48] It can also prevent harmful drug interactions, increase overall efficiency when prescribing medications, and reduce costs associated with healthcare.[49]

The question of who benefits from publicly funded genomics is an important public health consideration, and attention is needed to ensure that implementation of genomic medicine does not further entrench social‐equity concerns.[50]

Artificial intelligence in precision medicine

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Artificial intelligence is providing a paradigm shift toward precision medicine.[51] Machine learning algorithms are used for genomic sequence and to analyze and draw inferences from the vast amounts of data patients and healthcare institutions recorded in every moment.[52] AI techniques are used in precision cardiovascular medicine to understand genotypes and phenotypes in existing diseases, improve the quality of patient care, enable cost-effectiveness, and reduce readmission and mortality rates.[53] A 2021 paper reported that machine learning was able to predict the outcomes of Phase III clinical trials (for treatment of prostate cancer) with 76% accuracy.[54] This suggests that clinical trial data could provide a practical source for machine learning-based tools for precision medicine.

Precision medicine may be susceptible to subtle forms of algorithmic bias. For example, the presence of multiple entry fields with values entered by multiple observers can create distortions in the ways data is understood and interpreted.[55] A 2020 paper showed that training machine learning models in a population-specific fashion (i.e. training models specifically for Black cancer patients) can yield significantly superior performance than population-agnostic models.[56]

Precision Medicine Initiative

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In his 2015 State of the Union address, then-U.S. President Barack Obama stated his intention to give $215 million[57] of funding to the "Precision Medicine Initiative" of the United States National Institutes of Health.[58] A short-term goal of this initiative was to expand cancer genomics to develop better prevention and treatment methods.[59] In the long term, the Precision Medicine Initiative aimed to build a comprehensive scientific knowledge base by creating a national network of scientists and embarking on a national cohort study of one million Americans to expand our understanding of health and disease.[60] The mission statement of the Precision Medicine Initiative read: "To enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward development of individualized treatments".[61] In 2016 this initiative was renamed to "All of Us" and by January 2018, 10,000 people had enrolled in its pilot phase.[62]

Benefits of precision medicine

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Precision medicine helps health care providers better understand the many things—including environment, lifestyle, and heredity—that play a role in a patient's health, disease, or condition. This information lets them more accurately predict which treatments will be most effective and safe, or possibly how to prevent the illness from starting in the first place. In addition, benefits are to:[citation needed]

  • shift the emphasis in medicine from reaction to prevention
  • predict susceptibility to disease
  • improve disease detection
  • preempt disease progression
  • customize disease-prevention strategies
  • prescribe more effective drugs
  • avoid prescribing drugs with predictable negative side effects
  • reduce the time, cost, and failure rate of pharmaceutical clinical trials
  • eliminate trial-and-error inefficiencies that inflate health care costs and undermine patient care

Applications

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Advances in personalised medicine will create a more unified treatment approach specific to the individual and their genome. Personalised medicine may provide better diagnoses with earlier intervention, and more efficient drug development and more targeted therapies.[63]

Diagnosis and intervention

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Having the ability to look at a patient on an individual basis will allow for a more accurate diagnosis and specific treatment plan. Genotyping is the process of obtaining an individual's DNA sequence by using biological assays.[64] By having a detailed account of an individual's DNA sequence, their genome can then be compared to a reference genome, like that of the Human Genome Project, to assess the existing genetic variations that can account for possible diseases. A number of private companies, such as 23andMe, Navigenics, and Illumina, have created Direct-to-Consumer genome sequencing accessible to the public.[19] Having this information from individuals can then be applied to effectively treat them. An individual's genetic make-up also plays a large role in how well they respond to a certain treatment, and therefore, knowing their genetic content can change the type of treatment they receive.

An aspect of this is pharmacogenomics, which uses an individual's genome to provide a more informed and tailored drug prescription.[65] Often, drugs are prescribed with the idea that it will work relatively the same for everyone, but in the application of drugs, there are a number of factors that must be considered. The detailed account of genetic information from the individual will help prevent adverse events, allow for appropriate dosages, and create maximum efficacy with drug prescriptions.[19] For instance, warfarin is the FDA approved oral anticoagulant commonly prescribed to patients with blood clots. Due to warfarin's significant interindividual variability in pharmacokinetics and pharmacodynamics, its rate of adverse events is among the highest of all commonly prescribed drugs.[6] However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes, two genes that encode the individual anticoagulant response,[66][67] physicians can use patients' gene profile to prescribe optimum doses of warfarin to prevent side effects such as major bleeding and to allow sooner and better therapeutic efficacy.[6] The pharmacogenomic process for discovery of genetic variants that predict adverse events to a specific drug has been termed toxgnostics.[68]

An aspect of a theranostic platform applied to personalized medicine can be the use of diagnostic tests to guide therapy. The tests may involve medical imaging such as MRI contrast agents (T1 and T2 agents), fluorescent markers (organic dyes and inorganic quantum dots), and nuclear imaging agents (PET radiotracers or SPECT agents).[10][69] or in vitro lab test[70] including DNA sequencing[71] and often involve deep learning algorithms that weigh the result of testing for several biomarkers.[72]

In addition to specific treatment, personalised medicine can greatly aid the advancements of preventive care. For instance, many women are already being genotyped for certain mutations in the BRCA1 and BRCA2 gene if they are predisposed because of a family history of breast cancer or ovarian cancer.[73] As more causes of diseases are mapped out according to mutations that exist within a genome, the easier they can be identified in an individual. Measures can then be taken to prevent a disease from developing. Even if mutations were found within a genome, having the details of their DNA can reduce the impact or delay the onset of certain diseases.[63] Having the genetic content of an individual will allow better guided decisions in determining the source of the disease and thus treating it or preventing its progression. This will be extremely useful for diseases like Alzheimer's or cancers that are thought to be linked to certain mutations in our DNA.[63]

A tool that is being used now to test efficacy and safety of a drug specific to a targeted patient group/sub-group is companion diagnostics. This technology is an assay that is developed during or after a drug is made available on the market and is helpful in enhancing the therapeutic treatment available based on the individual.[74] These companion diagnostics have incorporated the pharmacogenomic information related to the drug into their prescription label in an effort to assist in making the most optimal treatment decision possible for the patient.[74]

 
An overall process of personalized cancer therapy. Genome sequencing will allow for a more accurate and personalized drug prescription and a targeted therapy for different patients.

Drug development and usage

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Having an individual's genomic information can be significant in the process of developing drugs as they await approval from the FDA for public use. Having a detailed account of an individual's genetic make-up can be a major asset in deciding if a patient can be chosen for inclusion or exclusion in the final stages of a clinical trial.[63] Being able to identify patients who will benefit most from a clinical trial will increase the safety of patients from adverse outcomes caused by the product in testing, and will allow smaller and faster trials that lead to lower overall costs.[75] In addition, drugs that are deemed ineffective for the larger population can gain approval by the FDA by using personal genomes to qualify the effectiveness and need for that specific drug or therapy even though it may only be needed by a small percentage of the population.,[63][76]

Physicians commonly use a trial and error strategy until they find the treatment therapy that is most effective for their patient.[63] With personalized medicine, these treatments can be more specifically tailored by predicting how an individual's body will respond and if the treatment will work based on their genome.[19] This has been summarized as "therapy with the right drug at the right dose in the right patient."[77] Such an approach would also be more cost-effective and accurate.[63] For instance, Tamoxifen used to be a drug commonly prescribed to women with ER+ breast cancer, but 65% of women initially taking it developed resistance. After research by people such as David Flockhart, it was discovered that women with certain mutation in their CYP2D6 gene, a gene that encodes the metabolizing enzyme, were not able to efficiently break down Tamoxifen, making it an ineffective treatment for them.[78] Women are now genotyped for these specific mutations to select the most effective treatment.

Screening for these mutations is carried out via high-throughput screening or phenotypic screening. Several drug discovery and pharmaceutical companies are currently utilizing these technologies to not only advance the study of personalised medicine, but also to amplify genetic research. Alternative multi-target approaches to the traditional approach of "forward" transfection library screening can entail reverse transfection or chemogenomics.[citation needed]

Pharmacy compounding is another application of personalised medicine. Though not necessarily using genetic information, the customized production of a drug whose various properties (e.g. dose level, ingredient selection, route of administration, etc.) are selected and crafted for an individual patient is accepted as an area of personalised medicine (in contrast to mass-produced unit doses or fixed-dose combinations). Computational and mathematical approaches for predicting drug interactions are also being developed. For example, phenotypic response surfaces model the relationships between drugs, their interactions, and an individual's biomarkers.[citation needed]

One active area of research is efficiently delivering personalized drugs generated from pharmacy compounding to the disease sites of the body.[7] For instance, researchers are trying to engineer nanocarriers that can precisely target the specific site by using real-time imaging and analyzing the pharmacodynamics of the drug delivery.[79] Several candidate nanocarriers are being investigated, such as iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles, and silica nanoparticles.[10] Alteration of surface chemistry allows these nanoparticles to be loaded with drugs, as well as to avoid the body's immune response, making nanoparticle-based theranostics possible.[7][10] Nanocarriers' targeting strategies are varied according to the disease. For example, if the disease is cancer, a common approach is to identify the biomarker expressed on the surface of cancer cells and to load its associated targeting vector onto nanocarrier to achieve recognition and binding; the size scale of the nanocarriers will also be engineered to reach the enhanced permeability and retention effect (EPR) in tumor targeting.[10] If the disease is localized in the specific organ, such as the kidney, the surface of the nanocarriers can be coated with a certain ligand that binds to the receptors inside that organ to achieve organ-targeting drug delivery and avoid non-specific uptake.[80] Despite the great potential of this nanoparticle-based drug delivery system, the significant progress in the field is yet to be made, and the nanocarriers are still being investigated and modified to meet clinical standards.[10][79]

Theranostics

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Main article: Theranostics

Theranostics is a personalized approach in nuclear medicine, using similar molecules for both imaging (diagnosis) and therapy.[81][82][83] The term is a portmanteau of "therapeutics" and "diagnostics". Its most common applications are attaching radionuclides (either gamma or positron emitters) to molecules for SPECT or PET imaging, or electron emitters for radiotherapy.[citation needed] One of the earliest examples is the use of radioactive iodine for treatment of people with thyroid cancer.[81] Other examples include radio-labelled anti-CD20 antibodies (e.g. Bexxar) for treating lymphoma, Radium-223 for treating bone metastases, Lutetium-177 DOTATATE for treating neuroendocrine tumors and Lutetium-177 PSMA for treating prostate cancer.[81] A commonly used reagent is fluorodeoxyglucose, using the isotope fluorine-18.[84]

Respiratory proteomics

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The preparation of a proteomics sample on a sample carrier to be analyzed by mass spectrometry

Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are nonspecific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a medical care approach that uses novel technology [85] aiming to personalize treatments according to the particular patient's medical needs. In specific, proteomics is used to analyze a series of protein expressions, instead of a single biomarker.[86] Proteins control the body's biological activities including health and disease, so proteomics is helpful in early diagnosis. In the case of respiratory disease, proteomics analyzes several biological samples including serum, blood cells, bronchoalveolar lavage fluids (BAL), nasal lavage fluids (NLF), sputum, among others.[86] The identification and quantification of complete protein expression from these biological samples are conducted by mass spectrometry and advanced analytical techniques.[87] Respiratory proteomics has made significant progress in the development of personalized medicine for supporting health care in recent years. For example, in a study conducted by Lazzari et al. in 2012, the proteomics-based approach has made substantial improvement in identifying multiple biomarkers of lung cancer that can be used in tailoring personalized treatments for individual patients.[88] More and more studies have demonstrated the usefulness of proteomics to provide targeted therapies for respiratory disease.[86]

Cancer genomics

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Over recent decades cancer research has discovered a great deal about the genetic variety of types of cancer that appear the same in traditional pathology. There has also been increasing awareness of tumor heterogeneity, or genetic diversity within a single tumor. Among other prospects, these discoveries raise the possibility of finding that drugs that have not given good results applied to a general population of cases may yet be successful for a proportion of cases with particular genetic profiles.

Personalized oncogenomics is the application of personalized medicine to cancer genomics. High-throughput sequencing methods are used to characterize genes associated with cancer to better understand disease pathology and improve drug development. Oncogenomics is one of the most promising branches of genomics, particularly because of its implications in drug therapy. Examples of this include:

  • Trastuzumab (trade names Herclon, Herceptin) is a monoclonal antibody drug that interferes with the HER2/neu receptor. Its main use is to treat certain breast cancers. This drug is only used if a patient's cancer is tested for over-expression of the HER2/neu receptor. Two tissue-typing tests are used to screen patients for possible benefit from Herceptin treatment. The tissue tests are immunohistochemistry(IHC) and Fluorescence In Situ Hybridization(FISH)[89] Only Her2+ patients will be treated with Herceptin therapy (trastuzumab)[90]
  • Tyrosine kinase inhibitors such as imatinib (marketed as Gleevec) have been developed to treat chronic myeloid leukemia (CML), in which the BCR-ABL fusion gene (the product of a reciprocal translocation between chromosome 9 and chromosome 22) is present in >95% of cases and produces hyperactivated abl-driven protein signaling. These medications specifically inhibit the Ableson tyrosine kinase (ABL) protein and are thus a prime example of "rational drug design" based on knowledge of disease pathophysiology.[91]
  • The FoundationOne CDx report produced by Foundation Medicine, which looks at genes in individual patients' tumor biopsies and recommends specific drugs
  • High mutation burden is indicative of response to immunotherapy, and also specific patterns of mutations have been associated with previous exposure to cytotoxic cancer drugs.[92]

Population screening

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See also: List of biobanks

Through the use of genomics (microarray), proteomics (tissue array), and imaging (fMRI, micro-CT) technologies, molecular-scale information about patients can be easily obtained. These so-called molecular biomarkers have proven powerful in disease prognosis, such as with cancer.[93][94][95] The main three areas of cancer prediction fall under cancer recurrence, cancer susceptibility and cancer survivability.[96] Combining molecular scale information with macro-scale clinical data, such as patients' tumor type and other risk factors, significantly improves prognosis.[96] Consequently, given the use of molecular biomarkers, especially genomics, cancer prognosis or prediction has become very effective, especially when screening a large population.[97] Essentially, population genomics screening can be used to identify people at risk for disease, which can assist in preventative efforts.[97]

Genetic data can be used to construct polygenic scores, which estimate traits such as disease risk by summing the estimated effects of individual variants discovered through a GWAS. These have been used for a wide variety of conditions, such as cancer, diabetes, and coronary artery disease.[98][99] Many genetic variants are associated with ancestry, and it remains a challenge to both generate accurate estimates and to decouple biologically relevant variants from those that are coincidentally associated. Estimates generated from one population do not usually transfer well to others, requiring sophisticated methods and more diverse and global data.[100][101] Most studies have used data from those with European ancestry, leading to calls for more equitable genomics practices to reduce health disparities.[102] Additionally, while polygenic scores have some predictive accuracy, their interpretations are limited to estimating an individual's percentile and translational research is needed for clinical use.[103]

Challenges

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As personalised medicine is practiced more widely, a number of challenges arise. The current approaches to intellectual property rights, reimbursement policies, patient privacy, data biases and confidentiality as well as regulatory oversight will have to be redefined and restructured to accommodate the changes personalised medicine will bring to healthcare.[104] For instance, a survey performed in the UK concluded that 63% of UK adults are not comfortable with their personal data being used for the sake of utilizing AI in the medical field.[105] Furthermore, the analysis of acquired diagnostic data is a recent challenge of personalized medicine and its implementation.[41] For example, genetic data obtained from next-generation sequencing requires computer-intensive data processing prior to its analysis.[106] In the future, adequate tools will be required to accelerate the adoption of personalised medicine to further fields of medicine, which requires the interdisciplinary cooperation of experts from specific fields of research, such as medicine, clinical oncology, biology, and artificial intelligence.

Regulatory oversight

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The U.S. Food and Drug Administration (FDA) has started taking initiatives to integrate personalised medicine into their regulatory policies. In October 2013, the agency published a report entitled "Paving the Way for Personalized Medicine: FDA's role in a New Era of Medical Product Development," in which they outlined steps they would have to take to integrate genetic and biomarker information for clinical use and drug development.[75] These included developing specific regulatory standards, research methods and reference materials.[75] An example of the latter category they were working on is a "genomic reference library", aimed at improving quality and reliability of different sequencing platforms.[75] A major challenge for those regulating personalized medicine is a way to demonstrate its effectiveness relative to the current standard of care.[107] The new technology must be assessed for both clinical and cost effectiveness, and as of 2013, regulatory agencies had no standardized method.[107]

Intellectual property rights

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As with any innovation in medicine, investment and interest in personalised medicine is influenced by intellectual property rights.[104] There has been a lot of controversy regarding patent protection for diagnostic tools, genes, and biomarkers.[108] In June 2013, the U.S. Supreme Court ruled that natural occurring genes cannot be patented, while "synthetic DNA" that is edited or artificially- created can still be patented. The Patent Office is currently reviewing a number of issues related to patent laws for personalised medicine, such as whether "confirmatory" secondary genetic tests post initial diagnosis, can have full immunity from patent laws. Those who oppose patents argue that patents on DNA sequences are an impediment to ongoing research while proponents point to research exemption and stress that patents are necessary to entice and protect the financial investments required for commercial research and the development and advancement of services offered.[108]

Reimbursement policies

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Reimbursement policies will have to be redefined to fit the changes that personalised medicine will bring to the healthcare system. Some of the factors that should be considered are the level of efficacy of various genetic tests in the general population, cost-effectiveness relative to benefits, how to deal with payment systems for extremely rare conditions, and how to redefine the insurance concept of "shared risk" to incorporate the effect of the newer concept of "individual risk factors".[104] The study, Barriers to the Use of Personalized Medicine in Breast Cancer, took two different diagnostic tests which are BRACAnalysis and Oncotype DX. These tests have over ten-day turnaround times which results in the tests failing and delays in treatments. Patients are not being reimbursed for these delays which results in tests not being ordered. Ultimately, this leads to patients having to pay out-of-pocket for treatments because insurance companies do not want to accept the risks involved.[109]

Patient privacy and confidentiality

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Perhaps the most critical issue with the commercialization of personalised medicine is the protection of patients. One of the largest issues is the fear and potential consequences for patients who are predisposed after genetic testing or found to be non-responsive towards certain treatments. This includes the psychological effects on patients due to genetic testing results. The right of family members who do not directly consent is another issue, considering that genetic predispositions and risks are inheritable. The implications for certain ethnic groups and presence of a common allele would also have to be considered.[104]

Moreover, we could refer to the privacy issue at all layers of personalized medicine from discovery to treatment. One of the leading issues is the consent of the patients to have their information used in genetic testing algorithms primarily AI algorithms. The consent of the institution who is providing the data to be used is of prominent concern as well.[105] In 2008, the Genetic Information Nondiscrimination Act (GINA) was passed in an effort to minimize the fear of patients participating in genetic research by ensuring that their genetic information will not be misused by employers or insurers.[104] On February 19, 2015, FDA issued a press release titled: "FDA permits marketing of first direct-to-consumer genetic carrier test for Bloom syndrome.[8]

Data biases

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Data biases also play an integral role in personalized medicine. It is important to ensure that the sample of genes being tested come from different populations. This is to ensure that the samples do not exhibit the same human biases we use in decision making.[110]

Consequently, if the designed algorithms for personalized medicine are biased, then the outcome of the algorithm will also be biased because of the lack of genetic testing in certain populations.[111] For instance, the results from the Framingham Heart Study have led to biased outcomes of predicting the risk of cardiovascular disease. This is because the sample was tested only on white people and when applied to the non-white population, the results were biased with overestimation and underestimation risks of cardiovascular disease.[112]

Implementation

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Several issues must be addressed before personalized medicine can be implemented. Very little of the human genome has been analyzed, and even if healthcare providers had access to a patient's full genetic information, very little of it could be effectively leveraged into treatment.[113] Challenges also arise when processing such large amounts of genetic data. Even with error rates as low as 1 per 100 kilobases, processing a human genome could have roughly 30,000 errors.[114] This many errors, especially when trying to identify specific markers, can make discoveries and verifiability difficult. There are methods to overcome this, but they are computationally taxing and expensive. There are also issues from an effectiveness standpoint, as after the genome has been processed, function in the variations among genomes must be analyzed using genome-wide studies. While the impact of the SNPs discovered in these kinds of studies can be predicted, more work must be done to control for the vast amounts of variation that can occur because of the size of the genome being studied.[114] In order to effectively move forward in this area, steps must be taken to ensure the data being analyzed is good, and a wider view must be taken in terms of analyzing multiple SNPs for a phenotype. The most pressing issue that the implementation of personalized medicine is to apply the results of genetic mapping to improve the healthcare system. This is not only due to the infrastructure and technology required for a centralized database of genome data, but also the physicians that would have access to these tools would likely be unable to fully take advantage of them.[114] In order to truly implement a personalized medicine healthcare system, there must be an end-to-end change.

The Copenhagen Institute for Futures Studies and Roche set up FutureProofing Healthcare[115] which produces a Personalised Health Index, rating different countries performance against 27 different indicators of personalised health across four categories called 'Vital Signs'. They have run conferences in many countries to examine their findings.[116][117]

See also

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References

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  1. ^ a b c Stratified, personalized or P4 medicine: a new direction for placing the patient at the center of healthcare and health education (Technical report). Academy of Medical Sciences. May 2015. Archived from the original on 27 October 2016. Retrieved 6 January 2016.
  2. ^ a b c "Many names for one concept or many concepts in one name?". PHG Foundation. Archived from the original on 9 November 2016. Retrieved 6 January 2015.
  3. ^ Egnew TR (1 March 2009). "Suffering, meaning, and healing: challenges of contemporary medicine". Annals of Family Medicine. 7 (2): 170–5. doi:10.1370/afm.943. PMC 2653974. PMID 19273873.
  4. ^ "The Case for Personalized Medicine" (PDF). Personalized Medicine Coalition. 2014. Retrieved 6 January 2016.
  5. ^ Smith R (15 October 2012). "Stratified, personalised, or precision medicine". British Medical Journal. Retrieved 6 January 2016.
  6. ^ a b c Lesko LJ (June 2007). "Personalized medicine: elusive dream or imminent reality?". Clinical Pharmacology and Therapeutics. 81 (6): 807–16. doi:10.1038/sj.clpt.6100204. PMID 17505496. S2CID 17860973.
  7. ^ a b c "Grand Challenges - Engineer Better Medicines". www.engineeringchallenges.org. Retrieved 3 August 2020.
  8. ^ a b "Personalized Medicine 101". Personalized Medicine Coalition. Archived from the original on 10 May 2019. Retrieved 26 April 2014.
  9. ^ Priyadharshini VS, Teran LM (2016). "Personalized Medicine in Respiratory Disease". Chapter Five - Personalized Medicine in Respiratory Disease: Role of Proteomics. Advances in Protein Chemistry and Structural Biology. Vol. 102. pp. 115–146. doi:10.1016/bs.apcsb.2015.11.008. ISBN 978-0-12-804795-8. PMID 26827604.
  10. ^ a b c d e f Xie J, Lee S, Chen X (August 2010). Donev R (ed.). "Nanoparticle-based theranostic agents". Advanced Drug Delivery Reviews. Personalized Medicine. 62 (11). Academic Press: 1064–79. doi:10.1016/j.addr.2010.07.009. PMC 2988080. PMID 20691229.
  11. ^ "What is the difference between precision medicine and personalized medicine? What about pharmacogenomics?". MedlinePlus, National Library of Medicine, US National Institutes of Health. 17 May 2022. Retrieved 24 April 2024.
  12. ^ a b "Precision medicine". National Human Genome Research Institute, US National Institutes of Health. 24 April 2024. Retrieved 24 April 2024.
  13. ^ Lu YF, Goldstein DB, Angrist M, et al. (July 2014). "Personalized medicine and human genetic diversity". Cold Spring Harbor Perspectives in Medicine (Essay). 4 (9): a008581. doi:10.1101/cshperspect.a008581. PMC 4143101. PMID 25059740.
  14. ^ Jones DT, Banito A, Grünewald TG, et al. (August 2019). "Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours". Nature Reviews Cancer (Review). 19 (8): 420–438. doi:10.1038/s41568-019-0169-x. PMID 31300807. S2CID 196350118.
  15. ^ a b "Personalized medicine". National Human Genome Research Institute, US National Institutes of Health. 24 April 2024. Retrieved 24 April 2024.
  16. ^ a b President’s Council of Advisors on Science and Technology (September 2008). "Priorities for Personalized Medicine" (PDF). The White House. p. 19. Archived from the original (PDF) on 10 June 2016. Retrieved 24 April 2024.
  17. ^ Clerk J (23 February 2015). "Changing medicine with 3-D bioprinting, where organs can be synthesized by technology". Los Angeles Times.
  18. ^ National Research Council (2011), "Glossary", Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, National Academies Press (US), retrieved 25 April 2024
  19. ^ a b c d Dudley J, Karczewski K (2014). Exploring Personal Genomics. Oxford: Oxford University Press.
  20. ^ a b "Personalized Medicine 101: The Science". Personalized Medicine Coalition. Archived from the original on 19 February 2019. Retrieved 26 April 2014.
  21. ^ Lu YF, Goldstein DB, Angrist M, et al. (July 2014). "Personalized medicine and human genetic diversity". Cold Spring Harbor Perspectives in Medicine. 4 (9): a008581. doi:10.1101/cshperspect.a008581. PMC 4143101. PMID 25059740.
  22. ^ Battle A, Mostafavi S, Zhu X, et al. (January 2014). "Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals". Genome Research. 24 (1): 14–24. doi:10.1101/gr.155192.113. PMC 3875855. PMID 24092820.
  23. ^ Cenik C, Cenik ES, Byeon GW, et al. (November 2015). "Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans". Genome Research. 25 (11): 1610–21. doi:10.1101/gr.193342.115. PMC 4617958. PMID 26297486.
  24. ^ Wu L, Candille SI, Choi Y, et al. (July 2013). "Variation and genetic control of protein abundance in humans". Nature. 499 (7456): 79–82. Bibcode:2013Natur.499...79W. doi:10.1038/nature12223. PMC 3789121. PMID 23676674.
  25. ^ Snyderman R (August 2012). "Personalized health care: from theory to practice". Biotechnology Journal. 7 (8): 973–9. doi:10.1002/biot.201100297. PMID 22180345. S2CID 31447416.
  26. ^ Altmann A, Beerenwinkel N, Sing T, et al. (2007). "Improved prediction of response to antiretroviral combination therapy using the genetic barrier to drug resistance". Antiviral Therapy. 12 (2): 169–78. doi:10.1177/135965350701200202. PMID 17503659. S2CID 26286925. INIST 18647009.
  27. ^ Blau CA, Liakopoulou E (24 October 2012). "Can we deconstruct cancer, one patient at a time?". Opinion. Trends in Genetics. 29 (1). CellPress: 6–10. doi:10.1016/j.tig.2012.09.004. PMC 4221262. PMID 23102584.
  28. ^ Tavassoly I, Hu Y, Zhao S, et al. (August 2019). "Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses". Molecular Oncology. 13 (8): 1725–1743. doi:10.1002/1878-0261.12521. PMC 6670022. PMID 31116490.
  29. ^ Garraway LA, Verweij J, Ballman KV (May 2013). "Precision oncology: an overview". Journal of Clinical Oncology. 31 (15): 1803–5. doi:10.1200/jco.2013.49.4799. PMID 23589545. S2CID 42163820.
  30. ^ Shrager J, Tenenbaum JM (February 2014). "Rapid learning for precision oncology". Nature Reviews. Clinical Oncology. 11 (2): 109–18. doi:10.1038/nrclinonc.2013.244. PMID 24445514. S2CID 11225698.
  31. ^ Fernandes BS, Williams LM, Steiner J, et al. (April 2017). "The new field of 'precision psychiatry'". BMC Medicine. 15 (1): 80. doi:10.1186/s12916-017-0849-x. PMC 5390384. PMID 28403846.
  32. ^ Fernandes BS, Berk M (June 2017). "Staging in bipolar disorder: one step closer to precision psychiatry". Revista Brasileira de Psiquiatria. 39 (2): 88–89. doi:10.1590/1516-4446-2017-3902. PMC 7111440. PMID 28591270.
  33. ^ Ogino S, Lochhead P, Chan AT, et al. (April 2013). "Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease". Modern Pathology. 26 (4): 465–84. doi:10.1038/modpathol.2012.214. PMC 3637979. PMID 23307060.
  34. ^ Ogino S, Fuchs CS, Giovannucci E (July 2012). "How many molecular subtypes? Implications of the unique tumor principle in personalized medicine". Expert Review of Molecular Diagnostics. 12 (6): 621–628. doi:10.1586/erm.12.46. PMC 3492839. PMID 22845482.
  35. ^ Ogino S, Lochhead P, Giovannucci E, et al. (June 2014). "Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology". Oncogene. 33 (23): 2949–55. doi:10.1038/onc.2013.244. PMC 3818472. PMID 23792451.
  36. ^ Haines JL, Hauser MA, Schmidt S, et al. (April 2005). "Complement factor H variant increases the risk of age-related macular degeneration". Science. 308 (5720): 419–21. Bibcode:2005Sci...308..419H. doi:10.1126/science.1110359. PMID 15761120. S2CID 32716116.
  37. ^ "A Catalog of Published Genome-Wide Association Studies". Retrieved 28 June 2015.
  38. ^ Ashley EA, Butte AJ, Wheeler MT, et al. (May 2010). "Clinical assessment incorporating a personal genome". Lancet. 375 (9725): 1525–35. doi:10.1016/s0140-6736(10)60452-7. PMC 2937184. PMID 20435227.
  39. ^ "Oncotype DX: Genomic Test to Inform Breast Cancer Treatment". 13 June 2019.
  40. ^ Precision Medicine: Harnessing the Extraordinary Growth in Medical Data for Personalized Diagnosis and Treatment http://claudiacopeland.com/uploads/3/6/1/4/3614974/hjno_novdec_2016_precision_medicine.pdf Archived 2022-11-13 at the Wayback Machine
  41. ^ a b Huser V, Sincan M, Cimino JJ (2014). "Developing genomic knowledge bases and databases to support clinical management: current perspectives". Pharmacogenomics and Personalized Medicine. 7: 275–83. doi:10.2147/PGPM.S49904. PMC 4175027. PMID 25276091.
  42. ^ Ashley EA (June 2015). "The precision medicine initiative: a new national effort". JAMA. 313 (21): 2119–20. doi:10.1001/jama.2015.3595. PMID 25928209.
  43. ^ Ashley EA (August 2016). "Towards precision medicine". Nature Reviews. Genetics. 17 (9): 507–22. doi:10.1038/nrg.2016.86. PMID 27528417. S2CID 2609065.
  44. ^ Splinter K, Adams DR, Bacino CA, et al. (29 November 2018). "Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease". New England Journal of Medicine. 379 (22): 2131–2139. doi:10.1056/NEJMoa1714458. PMC 6481166. PMID 30304647.
  45. ^ Serpico D, Maziarz M (14 December 2023). "Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response". European Journal for Philosophy of Science. 13 (4): 59. doi:10.1007/s13194-023-00559-0. ISSN 1879-4920.
  46. ^ Nikles, J., & Mitchell, G. (2015). Nikles J, Mitchell G (eds.). "The Essential Guide to N-of-1 Trials in Health" (PDF). SpringerLink. doi:10.1007/978-94-017-7200-6. ISBN 978-94-017-7199-3. S2CID 33597874.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  47. ^ "Divining your future in healthcare". pmlive.com. 18 October 2013.
  48. ^ "3D-Printed Medical Devices Spark FDA Evaluation". LiveScience.com. 30 August 2013.
  49. ^ "Personalized Medicine Benefits - The Jackson Laboratory". jax.org. Archived from the original on 10 May 2015. Retrieved 23 September 2022.
  50. ^ Belcher A, Mangelsdorf M, McDonald F, et al. (June 2019). "What does Australia's investment in genomics mean for public health?". Australian and New Zealand Journal of Public Health. 43 (3): 204–206. doi:10.1111/1753-6405.12887. PMID 30830712.
  51. ^ Mesko B (2017). "Expert Review of Precision Medicine and Drug Development". Journal Expert Review of Precision Medicine and Drug Development. 2 (5): 239–241. doi:10.1080/23808993.2017.1380516.
  52. ^ Ray A (20 May 2018). "Artificial Intelligence and Blockchain for Precision Medicine". Inner Light Publishers. Retrieved 21 May 2018.
  53. ^ Krittanawong C, Zhang H, Wang Z, et al. (May 2017). "Artificial Intelligence in Precision Cardiovascular Medicine". Journal of the American College of Cardiology. 69 (21): 2657–2664. doi:10.1016/j.jacc.2017.03.571. PMID 28545640.
  54. ^ Beacher FD, Mujica-Parodi LR, Gupta S, et al. (5 May 2021). "Machine Learning Predicts Outcomes of Phase III Clinical Trials for Prostate Cancer". Algorithms. 14 (5): 147. doi:10.3390/a14050147.
  55. ^ Ferryman K, Pitcan M (26 February 2018). "Fairness in Precision Medicine". Data & Society. Retrieved 27 October 2021.
  56. ^ Bhargava HK, Leo P, Elliott R, et al. (15 April 2020). "Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients". Clinical Cancer Research. 26 (8): 1915–1923. doi:10.1158/1078-0432.CCR-19-2659. ISSN 1557-3265. PMC 7165025. PMID 32139401.
  57. ^ "The Impact of Precision Medicine on Cancer". weillcornell.org.
  58. ^ "Obama proposes 'precision medicine 'to end one-size-fits-all". AP News. 30 January 2015. Retrieved 20 April 2024.
  59. ^ "Near-term Goals". nih.gov.
  60. ^ "Longer-term Goals". nih.gov.
  61. ^ "The White House Precision Medicine Initiative". whitehouse.gov – via National Archives.
  62. ^ Cunningham PW (16 January 2018). "The Health 202: NIH wants 1 million Americans to contribute to new pool of gene data". The Washington Post. ISSN 0190-8286. Retrieved 20 January 2018.
  63. ^ a b c d e f g "Personalized Medicine 101: The Promise". Personalized Medicine Coalition. Archived from the original on 19 December 2017. Retrieved 26 April 2014.
  64. ^ "Research Portfolio Online Reporting Tools: Human Genome Project". National Institutes of Health (NIH). Archived from the original on 25 September 2019. Retrieved 28 April 2014.
  65. ^ "Genetics Home Reference: What is pharmacogenomics?". National Institutes of Health (NIH). Retrieved 28 April 2014.
  66. ^ Breckenridge A, Orme M, Wesseling H, et al. (April 1974). "Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man". Clinical Pharmacology and Therapeutics. 15 (4): 424–30. doi:10.1002/cpt1974154424. PMID 4821443. S2CID 11777099.
  67. ^ Rieder MJ, Reiner AP, Gage BF, et al. (June 2005). "Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose". The New England Journal of Medicine. 352 (22): 2285–93. doi:10.1056/NEJMoa044503. PMID 15930419.
  68. ^ Church D, Kerr R, Domingo E, et al. (June 2014). "'Toxgnostics': an unmet need in cancer medicine". Nature Reviews. Cancer. 14 (6): 440–5. doi:10.1038/nrc3729. PMID 24827503. S2CID 21601547.
  69. ^ Kelkar SS, Reineke TM (October 2011). "Theranostics: combining imaging and therapy". Bioconjugate Chemistry. 22 (10): 1879–903. doi:10.1021/bc200151q. PMID 21830812.
  70. ^ Perkovic MN, Erjavec GN, Strac DS, et al. (March 2017). "Theranostic Biomarkers for Schizophrenia". International Journal of Molecular Sciences. 18 (4): 733. doi:10.3390/ijms18040733. PMC 5412319. PMID 28358316.
  71. ^ Kamps R, Brandão RD, Bosch BJ, et al. (January 2017). "Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification". International Journal of Molecular Sciences. 18 (2): 308. doi:10.3390/ijms18020308. PMC 5343844. PMID 28146134.
  72. ^ Yahata N, Kasai K, Kawato M (April 2017). "Computational neuroscience approach to biomarkers and treatments for mental disorders". Psychiatry and Clinical Neurosciences. 71 (4): 215–237. doi:10.1111/pcn.12502. PMID 28032396.
  73. ^ "Fact Sheet: BRCA1 and BRCA2: Cancer and Genetic Testing". National Cancer Institute (NCI). Retrieved 28 April 2014.
  74. ^ a b "BIOMARKER TOOLKIT: Companion Diagnostics" (PDF). Amgen. Archived from the original (PDF) on 1 August 2014. Retrieved 2 May 2014.
  75. ^ a b c d "Paving the Way for Personalized Medicine: FDA's Role in a New Era of Medical Product Development" (PDF). U.S. Food and Drug Administration (FDA). October 2013. Archived from the original (PDF) on 23 January 2014. Retrieved 28 April 2014.
  76. ^ Hamburg MA, Collins FS (July 2010). "The path to personalized medicine". The New England Journal of Medicine. 363 (4): 301–4. doi:10.1056/nejmp1006304. PMID 20551152. S2CID 205106671.
  77. ^ Mancinelli L, Cronin M, Sadée W (2000). "Pharmacogenomics: the promise of personalized medicine". AAPS PharmSci. 2 (1): 29–41. doi:10.1208/ps020104. PMC 2750999. PMID 11741220.
  78. ^ Ellsworth RE, Decewicz DJ, Shriver CD, et al. (May 2010). "Breast cancer in the personal genomics era". Current Genomics. 11 (3): 146–61. doi:10.2174/138920210791110951. PMC 2878980. PMID 21037853.
  79. ^ a b Soni A, Gowthamarajan K, Radhakrishnan A (March 2018). "Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management". International Journal of Pharmaceutical Compounding. 22 (2): 108–121. PMID 29877858.
  80. ^ Wang J, Poon C, Chin D, et al. (1 October 2018). "Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery". Nano Research. 11 (10): 5584–5595. doi:10.1007/s12274-018-2100-2. S2CID 104241223.
  81. ^ a b c Langbein T, Weber WA, Eiber M (September 2019). "Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine". Journal of Nuclear Medicine. 60 (Suppl 2): 13S–19S. doi:10.2967/jnumed.118.220566. PMID 31481583. S2CID 201830244.
  82. ^ Herrmann K, Schwaiger M, Lewis JS, et al. (March 2020). "Radiotheranostics: a roadmap for future development". The Lancet. Oncology. 21 (3): e146–e156. doi:10.1016/S1470-2045(19)30821-6. PMC 7367151. PMID 32135118.
  83. ^ Jadvar H, Chen X, Cai W, et al. (February 2018). "Radiotheranostics in Cancer Diagnosis and Management". Radiology. 286 (2): 388–400. doi:10.1148/radiol.2017170346. PMC 5790308. PMID 29356634.
  84. ^ Pandey S, Giovenzana GB, Szikra D, et al. (2021). "Chapter 11. Positron Emission Tomography (PET) Driven Theranostics". Metal Ions in Bio-Imaging Techniques. Springer. pp. 315–346. doi:10.1515/9783110685701-017. S2CID 233659232.
  85. ^ Priyadharshini VS, Teran LM (2016). "Personalized Medicine in Respiratory Disease: Role of Proteomics". Advances in Protein Chemistry and Structural Biology. 102: 115–46. doi:10.1016/bs.apcsb.2015.11.008. PMID 26827604.
  86. ^ a b c Priyadharshini VS, Teran LM (2020). "Role of respiratory proteomics in precision medicine". In Faintuch J, Faintuch S (eds.). Precision Medicine for Investigators, Practitioners and Providers. Academic Press. pp. 255–261. doi:10.1016/B978-0-12-819178-1.00024-1. ISBN 978-0-12-819178-1. S2CID 213865547.
  87. ^ Fujii K, Nakamura H, Nishimura T (April 2017). "Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma". Expert Review of Proteomics. 14 (4): 373–386. doi:10.1080/14789450.2017.1304215. PMID 28271730. S2CID 3640863.
  88. ^ Lazzari C, Spreafico A, Bachi A, et al. (January 2012). "Changes in plasma mass-spectral profile in course of treatment of non-small cell lung cancer patients with epidermal growth factor receptor tyrosine kinase inhibitors". Journal of Thoracic Oncology. 7 (1): 40–8. doi:10.1097/JTO.0b013e3182307f17. PMID 21964534. S2CID 205738875.
  89. ^ Carney W (2006). "HER2/neu Status is an Important Biomarker in Guiding Personalized HER2/neu Therapy" (PDF). Connection. 9: 25–27. Archived from the original (PDF) on 4 March 2016. Retrieved 3 January 2014.
  90. ^ Telli ML, Hunt SA, Carlson RW, et al. (August 2007). "Trastuzumab-related cardiotoxicity: calling into question the concept of reversibility". Journal of Clinical Oncology. 25 (23): 3525–33. doi:10.1200/JCO.2007.11.0106. PMID 17687157.
  91. ^ Saglio G, Morotti A, Mattioli G, et al. (December 2004). "Rational approaches to the design of therapeutics targeting molecular markers: the case of chronic myelogenous leukemia". Annals of the New York Academy of Sciences. 1028 (1): 423–31. Bibcode:2004NYASA1028..423S. doi:10.1196/annals.1322.050. PMID 15650267. S2CID 19332062.
  92. ^ Pleasance E, Titmuss E, Williamson L, et al. (2020). "Pan-cancer analysis of advanced patient tumours reveals interactions between therapy and genomic landscapes". Nature Cancer. 1 (4): 452–468. doi:10.1038/s43018-020-0050-6. PMID 35121966.
  93. ^ Duffy MJ (July 2001). "Biochemical markers in breast cancer: which ones are clinically useful?". Clinical Biochemistry. 34 (5): 347–52. doi:10.1016/S0009-9120(00)00201-0. PMID 11522269.
  94. ^ Piccart M, Lohrisch C, Di Leo A, et al. (2001). "The predictive value of HER2 in breast cancer". Oncology. 61 Suppl 2 (2): 73–82. doi:10.1159/000055405. PMID 11694791. S2CID 23123767.
  95. ^ Baldus SE, Engelmann K, Hanisch FG (1 January 2004). "MUC1 and the MUCs: a family of human mucins with impact in cancer biology". Critical Reviews in Clinical Laboratory Sciences. 41 (2): 189–231. doi:10.1080/10408360490452040. PMID 15270554. S2CID 46460945.
  96. ^ a b Cruz JA, Wishart DS (February 2007). "Applications of machine learning in cancer prediction and prognosis". Cancer Informatics. 2: 59–77. CiteSeerX 10.1.1.795.3458. doi:10.1177/117693510600200030. PMC 2675494. PMID 19458758.
  97. ^ a b Williams MS (August 2019). "Early Lessons from the Implementation of Genomic Medicine Programs". Annual Review of Genomics and Human Genetics. 20 (1): 389–411. doi:10.1146/annurev-genom-083118-014924. PMID 30811224. S2CID 73460688.
  98. ^ Thomas M, Sakoda LC, Hoffmeister M, et al. (September 2020). "Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk". Am J Hum Genet. 107 (3): 432–444. doi:10.1016/j.ajhg.2020.07.006. PMC 7477007. PMID 32758450.
  99. ^ Khera AV, Chaffin M, Aragam KG, et al. (September 2018). "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations". Nat Genet. 50 (9): 1219–1224. doi:10.1038/s41588-018-0183-z. PMC 6128408. PMID 30104762.
  100. ^ Marnetto D, Pärna K, Läll K, et al. (April 2020). "Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals". Nat Commun. 11 (1): 1628. Bibcode:2020NatCo..11.1628M. doi:10.1038/s41467-020-15464-w. PMC 7118071. PMID 32242022.
  101. ^ Wang Y, Guo J, Ni G, et al. (July 2020). "Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations". Nat Commun. 11 (1): 3865. Bibcode:2020NatCo..11.3865W. doi:10.1038/s41467-020-17719-y. PMC 7395791. PMID 32737319.
  102. ^ Martin AR, Kanai M, Kamatani Y, et al. (April 2019). "Clinical use of current polygenic risk scores may exacerbate health disparities". Nat Genet. 51 (4): 584–591. doi:10.1038/s41588-019-0379-x. PMC 6563838. PMID 30926966.
  103. ^ Lewis CM, Vassos E (May 2020). "Polygenic risk scores: from research tools to clinical instruments". Genome Med. 12 (1): 44. doi:10.1186/s13073-020-00742-5. PMC 7236300. PMID 32423490.
  104. ^ a b c d e "Personalized Medicine 101: The Challenges". Personalized Medicine Coalition. Archived from the original on 3 May 2014. Retrieved 26 April 2014.
  105. ^ a b Vayena E, Blasimme A, Cohen IG (November 2018). "Machine learning in medicine: Addressing ethical challenges". PLOS Medicine. 15 (11): e1002689. doi:10.1371/journal.pmed.1002689. PMC 6219763. PMID 30399149.
  106. ^ Schapranow MP (27 June 2013). "Analyze Genomes: Motivation". Hasso Plattner Institute. Retrieved 20 July 2014.
  107. ^ a b Frueh FW (September 2013). "Regulation, reimbursement, and the long road of implementation of personalized medicine--a perspective from the United States". Value in Health. 16 (6 Suppl): S27-31. doi:10.1016/j.jval.2013.06.009. PMID 24034309.
  108. ^ a b "Intellectual Property Issues Impacting the Future of Personalized Medicine". American Intellectual Property Law Association. Retrieved 26 April 2014.[dead link]
  109. ^ Weldon CB, Trosman JR, Gradishar WJ, et al. (July 2012). "Barriers to the use of personalized medicine in breast cancer". Journal of Oncology Practice. 8 (4): e24-31. doi:10.1200/jop.2011.000448. PMC 3396824. PMID 23180995.
  110. ^ Char DS, Shah NH, Magnus D (March 2018). "Implementing Machine Learning in Health Care - Addressing Ethical Challenges". The New England Journal of Medicine. 378 (11): 981–983. doi:10.1056/NEJMp1714229. PMC 5962261. PMID 29539284.
  111. ^ Chernew ME, Landrum MB (March 2018). "Targeted Supplemental Data Collection - Addressing the Quality-Measurement Conundrum". The New England Journal of Medicine. 378 (11): 979–981. doi:10.1056/NEJMp1713834. PMID 29539286.
  112. ^ Gijsberts CM, Groenewegen KA, Hoefer IE, et al. (2 July 2015). "Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events". PLOS ONE. 10 (7): e0132321. Bibcode:2015PLoSO..1032321G. doi:10.1371/journal.pone.0132321. PMC 4489855. PMID 26134404.
  113. ^ Yngvadottir B, Macarthur DG, Jin H, et al. (2009). "The promise and reality of personal genomics". Genome Biology. 10 (9): 237. doi:10.1186/gb-2009-10-9-237. PMC 2768970. PMID 19723346.
  114. ^ a b c Fernald GH, Capriotti E, Daneshjou R, et al. (July 2011). "Bioinformatics challenges for personalized medicine". Bioinformatics. 27 (13): 1741–8. doi:10.1093/bioinformatics/btr295. PMC 3117361. PMID 21596790.
  115. ^ "Personalised and precise healthcare means a better quality of life for patients". future proofing healthcare. Retrieved 17 November 2022.
  116. ^ "Building long term sustainable and personalised healthcare systems". Economist. 28 January 2021. Retrieved 17 November 2022.
  117. ^ "Ireland performs poorly on international index of personalised healthcare". Irish Medical Times. 9 September 2021. Retrieved 17 November 2022.
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