SXT may refer to:
- Soft X-ray transient or X-ray nova
- soft X-ray telescope, a telescope that views soft X-rays
- Saxitoxin
- Co-trimoxazole
- SXT Technology Solutions, a European telecommunications company
- the ICAO airline code for Servicios De Taxi Aéreo, see Airline codes-S
- the rail code for Salem Town railway station
- the NYSE stock ticker symbol for Sensient Technologies Corporation
- the sign extend operation for the PDP-11 architecture
- SXT the former trim model for a Dodge Grand Caravan.