Monocarboxylate transporter 3

SLC16A8
Identifiers
Aliases	SLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDs	OMIM: 610409; MGI: 1929519; HomoloGene: 75006; GeneCards: SLC16A8; OMA:SLC16A8 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,084,184 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,138,961 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; testicle; ; nucleus accumbens; ; sural nerve; ; gonad; ; C1 segment; ; right uterine tube; ; putamen; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; Epithelium of choroid plexus; ; gastrula; ; embryo; ; CA3 field; ; ciliary body; ; embryo; ; saccule; ; ectoderm;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; lactate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity;
Cellular component	integral component of plasma membrane; plasma membrane; membrane; integral component of membrane;
Biological process	monocarboxylic acid transport; pyruvate metabolic process; leukocyte migration; lactate transport; transmembrane transport; lactate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23539
	57274
	ENSG00000100156
	ENSMUSG00000032988
	O95907
	O35308
	NM_013356; NM_001394131
	NM_020516
	NP_037488
	NP_065262
	Wikidata
View/Edit Human	View/Edit Mouse

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.^[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100156 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032988 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.

Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics. 60 (3): 366–70. doi:10.1006/geno.1999.5926. PMID 10493836.
Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 18: 377–87. doi:10.1016/B978-0-12-152818-8.50028-1. ISBN 9780121528188. PMID 7273846.
Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100156 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032988 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.

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Monocarboxylate transporter 3

See also

References

Further reading