DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD+), polynucleotide ligase (NAD+), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).[1] This enzyme catalyses the following chemical reaction
| DNA ligase (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.5.1.2 | ||||||||
| CAS no. | 37259-52-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.
See also
editReferences
edit- ^ Zimmerman SB, Little JW, Oshinsky CK, Gellert M (June 1967). "Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide". Proceedings of the National Academy of Sciences of the United States of America. 57 (6): 1841–8. Bibcode:1967PNAS...57.1841Z. doi:10.1073/pnas.57.6.1841. PMC 224555. PMID 4291949.
External links
edit- DNA+ligase+(NAD+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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