Paul Barnes may refer to:
- Paul Barnes (musician) (1901–1981), American clarinetist and saxophonist
- Paul Barnes (pastor) (born 1954), former senior pastor of Grace Chapel in Douglas County, Colorado
- Paul Barnes (pianist) (born 1961), American pianist and Liszt specialist
- Paul Barnes (footballer) (born 1967), English footballer
- Paul Barnes (designer) (born 1970), prominent figure of modern UK graphic design
- Paul Barnes (songwriter) (1870–1922), vaudeville comedic actor, singer, pianist, and songwriter