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Nathan H. Lents

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Nathan H. Lents is an American scientist, author, and university professor. He has been on the faculty of John Jay College since 2006[1] and is currently the director of the Cell and Molecular Biology program and the former head of the honors program and the campus Macaulay Honors College program.[2] Lents is noted for his work in cell biology, genetics, and forensic science, as well as his popular science writing and blogging on the evolution of human biology and behavior. Lents is also a visiting faculty member at the University of Lincoln in the UK and a fellow with the Committee for Skeptical Inquiry.

Nathan H. Lents
Nathan H. Lents in 2017
Nathan H. Lents in 2017
Born1978
OccupationAuthor
Professor
NationalityAmerican
GenrePopular Science
Website
nathanlents.wordpress.com

Early life and education

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Lents was born and raised in Decatur, Illinois and graduated from St. Teresa High School.[3] He then attended Saint Louis University and graduated summa cum laude with a B.S degree in biology.[citation needed]

Lents moved to Saint Louis University School of Medicine for his doctoral work and graduated with a Ph.D. in Pharmacological and Physiological Sciences in 2004.[4] He completed postdoctoral training in cancer genomics at NYU Medical Center under the direction of Brian David Dynlacht.[5] He then joined the faculty of forensic science at John Jay College and the doctoral faculty of biochemistry at the CUNY Graduate Center.[citation needed]

Lents was promoted to Associate Professor with tenure in 2011 and attained the rank of full professor at John Jay College in 2016, his tenth year on the faculty.[6]

Research

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While an undergraduate at Saint Louis University in the 1990s, Lents conducted research with Biology Department chair Robert I. Bolla on the biochemical interactions between soybean plants and the soybean cyst nematode, a key cause of soybean crop loss in the United States. Specifically, he discovered that the CF-9 gene cluster correlated with resistance to nematodes in soybean strains.[citation needed]

During this same time period, Lents also worked in the fermentation research division of agribusiness giant Archer Daniels Midland, conducting basic microbiology research on the soil bacteria Corynebacterium glutamicum, which is used in the production of amino acids for food additives. Specifically, he worked on the production of lysine, a product that was the subject of a global price-fixing conspiracy. ADM plead guilty to antitrust violations and was forced to pay $100 million, the largest antitrust fine in US history. Several top ADM executives served prison sentences, but none of the scientists in the lysine group were implicated in any wrongdoing.[citation needed]

Since 2000, Lents has published research reports in the area of cell and cancer biology, genetics, forensic science, as well as the teaching and learning of science, particularly evolution.[7] Lents has been funded by the National Institutes of Health, National Science Foundation, Susan G. Komen Breast Cancer Foundation, and the US Department of Education.[6] His early work focused on the cell cycle and cancer biology, particularly the G1 to S phase transition. Specifically, Lents and colleagues showed that activation of the MAP kinase cascade is necessary and sufficient for a key phosphorylation step in the activation of cyclin-dependent kinase 2, an important cell cycle enzyme.[8] In addition, as a PhD student, Lents developed an innovative "reverse mutational" approach to discovering key phosphorylation sites on the Retinoblastoma protein, one of the most important tumor suppressors.[9]

In 2008, Lents discovered a new splice variant for the Mdm2 oncogene that is induced upon treatment with DNA-damaging cancer chemotherapies.[10] His laboratory later discovered new genetic connections between Vitamin D, the transcription factor MZF1, and the CCN gene family,[11] work that has led him and others to call for exploration of the usefulness of vitamin D as a possible enhancement for cancer treatments.[12]

Lents has also published research in the area of forensic biology and toxicology. His laboratory was among the first to note that zinc supplements can be effective in masking the presence of certain drug metabolites during routine drug testing.[13] In 2016, he published work on the skin microbiome of decomposing human cadavers.[14] He also developed and patented a DNA-based forensic method of species identification of trace plant material.[15]

Most recently, Lents has turned his research focus to the evolutionary genetics of human uniqueness. His laboratory recently discovered a set of microRNA genes on human chromosome 21 that are not shared with other apes and that appear to have originated de novo through genomic rearrangements.[16]

Books

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In 2016, Lents published his first book, Not So Different: Finding Human Nature in Animals with Columbia University Press. The book received favorable reviews from Publishers Weekly, The Quarterly Review of Biology, Psychology Today, and several others.[17] According to Lents, "…by exploring why animals behave as they do, we learn a lot about ourselves." He says the book is really about us, it only pretends to be about animals.[18]

In 2018, Houghton Mifflin Harcourt published his second book, Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes,[19] which was listed by Publishers Weekly as a "Big Title" for spring 2018 in the Science category.[20] Lents said his goal was to: "dispel two big misconceptions: that evolution produces perfection or anything like it, and that humans are the pinnacle of evolution."[21] Lents explains that humans no longer need to rely on the body's physical ability because we learned to solve life's challenges by using our brains to invent tools and our social capabilities to allow for division of labor and cooperation.[18] Human Errors received many favorable reviews and was included on recommended summer reading lists in The Wall Street Journal, Discover Magazine, EndPoints, the Financial Times, and was "Book of the Month" for August 2018 in Geographical Magazine.[22]

Lents's next book will be published in February 2025 by HarperCollins and is tentatively titled The Sexual Evolution: How 500 Million Years of Sex, Gender, and Mating Shape Modern Relationships.[23] Its subject will be the evolution of sex, gender, sexuality, and sexual relationships, and it will discuss how agriculture and civilization constrained and narrowed the diverse sexual expression of prehistoric humans. Lents will argue that human sexuality is "diverse, flexible, and adaptable", able to conform to the mandates of heteronormative power structures but not inherently monogamous.[24]

Intelligent Design criticism

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Lents' book Human Errors elicited much criticism from supporters of Intelligent Design. Even though the book was intended for an audience that accepted the scientific consensus on evolution, it does argue that the quirks of evolution, not an intelligent designer, account for the flaws in the human body.[24][25] Lents was thrust into the public eye as a defender of evolutionary science, especially in the context of education and politics in the United States. As part of this debate, Lents and a few colleagues deconstructed and rebutted a popular book on Intelligent Design, Darwin Devolves: The New Science About DNA That Challenges Evolution, written by creationist and biochemist Michael Behe. According to Lents, the exercise provided an opportunity both to clarify how evolution actually works and "how strongly bias can affect your interpretation of evidence". A version of this critique was published in the journal Science.[24][26] Proponents of Intelligent Design reacted with a flurry of negative articles, but Lents responded to their arguments and personal attacks by keeping the discussion focused on the science.[21]

Science education

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Lents has had articles published in journals and magazines, including Skeptic Magazine, The Wall Street Journal, The Observer, Psychology Today,[27] and The Chronicle of Higher Education.[citation needed] He regularly contributes modules for the Visionlearning science education project. He also maintains The Human Evolution Blog and authors most of its content.[28] He blogs for Psychology Today under the tagline "Beastly Behavior: How Evolution Shaped Our Minds and Bodies."[29]

Lents is the host and executive producer of the This World of Humans podcast, a collaboration with the Visionlearning project, focusing on new research in the area of biology and social science.[30]

In 2019, Lents was a featured presenter at CSICon, speaking about "Human Errors: What Our Quirks Tell Us about Our Past".[18]

As of 2022, Lents is a fellow with the Committee for Skeptical Inquiry.[31]

Media coverage

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Lents has appeared on television, radio, and news articles commenting about forensic science, human evolution, and other science issues. His television appearances have included The Today Show,[32] 48 Hours,[33] The Whole Story with Anderson Cooper (CNN),[34] Access Hollywood,[35] The Brian Lehrer Show,[36] BBC World Service Television,[37] and Al Jazeera.[38]

Lents's work has been quoted by various publications, including the Associated Press, Vice, The New York Times, Scientific American and others.[39] His blog has been quoted by USA Today, the Daily Mirror, the Daily Mail, The Daily Telegraph, New York Magazine, the New York Post, IFL Science, People Magazine, and was mentioned on Live with Kelly and Ryan.[citation needed]

Personal life

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Lents and his husband [40] Oscar live in Queens and have two children.[citation needed] In an April 2020 article for Psychology Today, Lents chronicled his personal battle with COVID-19.[41]

References

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  1. ^ "Nathan H. Lents". John Jay College of Criminal Justice. 2014-03-23. Retrieved 2022-02-14.
  2. ^ "Nathan H. Lents". John Jay College of Criminal Justice. 23 March 2014. Retrieved 9 May 2020.
  3. ^ Lents, Nathan H (2004). CDK2, CAK, and pRB: interactions regulating G1 phase cell cycle progression (PhD Thesis). OCLC 123984250.[page needed]
  4. ^ "Inaugural Distinguished Alumnus Award and Lecture". SLU Calendar.
  5. ^ "Dynlacht Lab – NYU Cancer Institute – NYU School of Medicine". med.nyu.edu.
  6. ^ a b "NATHAN H. LENTS: Professor of Biology". jjay.cuny.edu. John Jay College of Criminal Justice. 23 March 2014. Archived from the original on 2 May 2020. Retrieved 2 May 2020.
  7. ^ "Nathan H. Lents". scholar.google.com. Retrieved 2023-08-10.
  8. ^ Lents, Nathan H; Keenan, Susan M; Bellone, Clifford; Baldassare, Joseph J (2002). "Stimulation of the Raf/MEK/ERK Cascade is Necessary and Sufficient for Activation and Thr-160 Phosphorylation of a Nuclear-targeted CDK2". Journal of Biological Chemistry. 277 (49): 47469–75. doi:10.1074/jbc.M207425200. PMID 12359725.
  9. ^ Lents, Nathan H; Gorges, Laura L; Baldassare, Joseph J (2014). "Reverse Mutational Analysis Reveals Threonine-373 as a Potentially Sufficient Phosphorylation Site for Inactivation of the Retinoblastoma Tumor Suppressor Protein (pRB)". Cell Cycle. 5 (15): 1699–707. doi:10.4161/cc.5.15.3126. PMID 16880741.
  10. ^ Lents, Nathan H; Wheeler, Leroy W; Baldassare, Joseph J; Dynlacht, Brian David (2008). "Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents Adriamycin and Actinomycin D". Cell Cycle. 7 (11): 1580–6. doi:10.4161/cc.7.11.5985. PMC 3608406. PMID 18469520.
  11. ^ Piszczatowski, Richard T; Rafferty, Brian J; Rozado, Andre; Parziale, James V; Lents, Nathan H (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–9. doi:10.1002/jcp.25021. PMID 25899830. S2CID 6888015.
  12. ^ Piszczatowski, Richard T; Lents, Nathan H (2016). "Regulation of the CCN genes by vitamin D: A possible adjuvant therapy in the treatment of cancer and fibrosis". Cellular Signalling. 28 (10): 1604–13. doi:10.1016/j.cellsig.2016.07.009. PMID 27460560.
  13. ^ Venkatratnam, Abhishek (1 July 2011). "Zinc Reduces the Detection of Cocaine, Methamphetamine, and THC by ELISA Urine Testing". Journal of Analytical Toxicology. 35 (6): 333–340. doi:10.1093/anatox/35.6.333. PMID 21740689.
  14. ^ Johnson, Hunter R.; Trinidad, Donovan D.; Guzman, Stephania; Khan, Zenab; Parziale, James V.; DeBruyn, Jennifer M.; Lents, Nathan H. (22 December 2016). "A Machine Learning Approach for Using the Postmortem Skin Microbiome to Estimate the Postmortem Interval". PLOS ONE. 11 (12): e0167370. Bibcode:2016PLoSO..1167370J. doi:10.1371/journal.pone.0167370. PMC 5179130. PMID 28005908.
  15. ^ Srivastava, Tushar; Wu, Michael; Kakhnovich, Julia; Waithaka, Bridgit; Lents, Nathan H (2017). "A Three-Locus, PCR-based Method for Forensic Identification of Plant Material". Journal of Forensic Sciences. 63 (4): 1252–1260. doi:10.1111/1556-4029.13715. PMID 29194624. S2CID 206919448.
  16. ^ Hunter R. Johnson; Jessica A. Blandino; Beatriz C. Mercado; José A. Galván; William J. Higgins; Nathan H. Lents (June 2022). "The evolution of de novo human-specific microRNA genes on chromosome 21". American Journal of Biological Anthropology. 178 (2): 223–243. doi:10.1002/ajpa.24504. S2CID 247240062.
  17. ^ "Book: Not So Different". 2 May 2016.
  18. ^ a b c Gerbic, Susan (7 August 2019). ""Human Errors: What Our Quirks Tell Us About Our Past." — An Interview With Nathan Lents". Skeptical Inquirer. Retrieved October 27, 2019.
  19. ^ Lents, Nathan H. (2018). Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes. Houghton Mifflin Harcourt. ISBN 978-1328974693.
  20. ^ Segura, Jonathan. "Spring 2018 Adult Announcements". PublishersWeekly.com.
  21. ^ a b Palmer, Rob (3 May 2021). "Nathan H. Lents on Our Not So Intelligent Design". Skeptical Inquirer. Archived from the original on 3 May 2021. Retrieved 3 May 2021.
  22. ^ "Book: Human Errors". 2017-10-16.
  23. ^ "Canongate nabs a 'meticulously researched' book on sexuality and the natural world".
  24. ^ a b c Palmer, Rob (7 September 2022). "Anticipating CSICon 2022: An Interview with Nathan H. Lents". Skeptical Inquirer. Archived from the original on 12 September 2022. Retrieved 24 September 2022.
  25. ^ Hall, Harriet (May–June 2020). "Evolution's Flaws Are in Us". Skeptical Inquirer. Vol. 44, no. 3. Amherst, New York: Center for Inquiry. pp. 62–64. Archived from the original on 22 October 2020. Retrieved 1 January 2021.
  26. ^ Lents, Nathan; Swamidass, S. Joshua; Lenski, Richard E. (8 February 2019). ""The end of evolution?"". Science. 363 (6427): 590. Bibcode:2019Sci...363..590L. doi:10.1126/science.aaw4056. S2CID 59621727.
  27. ^ "Nathan H. Lents, Ph.D. | Psychology Today". www.psychologytoday.com.
  28. ^ Lents, Nathan. "The Human Evolution Blog". thehumanevolutionblog.com. Nathan Lents. Archived from the original on 2 May 2020. Retrieved 2 May 2020.
  29. ^ "Beastly Behavior". Psychology Today.
  30. ^ Website for This World of Humans podcast: www.visionlearning.com/en/twoh
  31. ^ "Committee for Skeptical Inquiry Elects 14 New Fellows from Six Countries". Skeptical Inquirer. 1 February 2022. Archived from the original on 17 September 2022. Retrieved 19 September 2022.
  32. ^ "Study: Handbags carry more bacteria than some toilets". TODAY.com.
  33. ^ "Nathan Lents on 48 hours". CBS News. 7 June 2014.
  34. ^ "The Whole Story with Anderson Cooper". CNN. Retrieved 2023-08-10.
  35. ^ "Exclusive: New Forensic Test Could Be Steven Avery's 'Secret Weapon' | Access Online". Access. 4 February 2016.
  36. ^ "People – Nathan Lents". www.wnyc.org.
  37. ^ "The Why Factor, The Family Tree". BBC World Service.
  38. ^ "3 inventions that can catch you committing a crime". america.aljazeera.com.
  39. ^ Rosenberg, Eli (2016-07-15). "K2's Sudden Surge Tests New York Authorities". The New York Times.
  40. ^ Shostak, Stanley (17 February 2017). "Not So Different: Finding Human Nature in Animals". The European Legacy. 22 (4): 507–509. doi:10.1080/10848770.2017.1291895. S2CID 151502205.
  41. ^ Lents, Nathan H. "I'm 41, Healthy, and Fit. And COVID-19 Still Got Me". psychologytoday.com/. Psychology Today. Retrieved 19 August 2020. My husband and I made the decision to keep my illness from all of our friends and family until I recovered. Our mothers are both worriers, and we saw no value in adding to their already excessive worry about us when there was absolutely nothing they (or anyone) could do to help us. My mom will be angry with me for some time, but I still think I made the right decision, especially since she's been checking on me constantly even though I'm now recovered.
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