Gold Nanocages are hollow, porous gold nanoparticles ranging in size from 10 to over 150 nm. They are created by reacting silver nanoparticles with chloroauric acid (HAuCl4) in boiling water.[1] Whereas gold nanoparticles absorb light in the visible spectrum of light (at about 550 nm), gold nanocages absorb light in the near-infrared,[2] where biological tissues absorb the least light. Because they are also biocompatible, gold nanocages are promising as a contrast agent for optical coherence tomography. Gold nanocages also absorb light and heat up (Photothermal effect), killing surrounding cancer cells. Nanocages have been functionalized with cancer-specific antibodies.[3][4]
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References
edit- ^ Skrabalak, S. E.; Chen, J.; Sun, Y.; Lu, X.; Au, L.; Cobley, C. M.; Xia, Y. (2008). "Gold nanocages: Synthesis, properties, and applications". Accounts of Chemical Research. 41 (12): 1587–95. doi:10.1021/ar800018v. PMC 2645935. PMID 18570442.
- ^ Yavuz, Mustafa S.; Cheng, Yiyun; Chen, Jingyi; Cobley, Claire M.; Zhang, Qiang; Rycenga, Matthew; Xie, Jingwei; Kim, Chulhong; Song, Kwang H.; Schwartz, Andrea G.; Wang, Lihong V.; Xia, Younan (2009). "Gold nanocages covered by smart polymers for controlled release with near-infrared light". Nature Materials. 8 (12): 935–939. Bibcode:2009NatMa...8..935Y. doi:10.1038/nmat2564. PMC 2787748. PMID 19881498.
- ^ Jingyi Chen; Fusayo Saeki; Benjamin J. Wiley; Hu Cang; Michael J. Cobb; Zhi-Yuan Li; Leslie Au; Hui Zhang; Michael B. Kimmey; Xingde Li; Younan Xia (2005). "Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents". Nano Lett. 5 (3): 473–7. Bibcode:2005NanoL...5..473C. doi:10.1021/nl047950t. PMID 15755097.
- ^ Au, L.; Zheng, D.; Zhou, F.; Li, Z. Y.; Li, X.; Xia, Y. (2008). "A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells". ACS Nano. 2 (8): 1645–52. doi:10.1021/nn800370j. PMC 2718847. PMID 19206368.
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