Neuropeptides B/W receptor 2

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.

NPBWR2
Identifiers
Aliases	NPBWR2, GPR8, Neuropeptides B/W receptor 2, neuropeptides B and W receptor 2
External IDs	OMIM: 600731; HomoloGene: 128565; GeneCards: NPBWR2; OMA:NPBWR2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 64,103,802 bp End 64,107,565 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 right frontal lobe pituitary gland anterior pituitary anterior cingulate cortex adrenal gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled opioid receptor activity neuropeptide binding protein binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity peptide binding Cellular component integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled opioid receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2832 n/a Ensembl ENSG00000125522 ENSG00000277339 n/a UniProt P48146 n/a RefSeq (mRNA) NM_005286 n/a RefSeq (protein) NP_005277 n/a Location (UCSC) Chr 20: 64.1 – 64.11 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.

See also

• Neuropeptide B/W receptor

Further reading

• O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain". Genomics. 28 (1): 84–91. doi:10.1006/geno.1995.1109. PMID 7590751.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
• Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. Bibcode:2003PNAS..100.6251T. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.

External links

• "Neuropeptide B/W Receptors: NPBW2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.