Khamsa (Arabic, lit.'five' or 'quintet') may refer to:

  • Hamsa, a popular amulet in the Middle East and North Africa, also romanized as khamsa
  • Al Khamsa, a bloodline for Arabian horses that traces back to five mares
  • Al Khamsa (organization), a nonprofit organization in the United States that supports the breeding of Al Khamsa bloodline horses
  • Khamseh, a tribal people of Iran
  • Khamsa (film), a 2008 film
  • Khamsa, a quintet of five long Persian poems, such as the Khamsa of Nizami Ganjavi or that of Hatefi

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