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Summary
| Description |
English: Following DNA damage, TopBP1 is phosphorylated by Akt and self oligomerizes at the BRCT7/8 domains. Oligomeric TopBP1 can bind to E2F-1 and recruit chromatin remodeling machinery (e.g. HDAC) to repress E2F-1 driven gene expression. |
| Date | |
| Source | Own work |
| Author | Cpt01 |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 22:43, 28 November 2022 | | 2,207 × 905 (253 KB) | Cpt01 | reformatted shapes |
| 22:45, 27 November 2022 |  | 2,207 × 905 (79 KB) | Cpt01 | Uploaded own work with UploadWizard |
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