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File:Thymidylate synthase 1HVY.png

Thymidylate_synthase_1HVY.png (757 × 584 pixels, file size: 448 KB, MIME type: image/png)

Description

Ribbon diagram of human thymidylate synthase in complex with deoxyuridine monophosphate (orange) and the enzyme inhibitor raltitrexed (lime green).
Created using PyMOL (http://www.pymol.org) and GIMP.

Legend
 
A unit
 
B unit
 
Deoxyuridine monophosphate (dUMP)
 
Raltitrexed
Date
Source

From PDB entry 1HVY. More information:

  • Phan J, Koli S, Minor W, Dunlap RB, Berger SH, Lebioda L (2001). "Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug". Biochemistry 40 (7): 1897–902. PMID 11329255.
Author Fvasconcellos 17:46, 28 August 2007 (UTC)
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28 August 2007

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Date/TimeThumbnailDimensionsUserComment
current01:52, 31 August 2010Thumbnail for version as of 01:52, 31 August 2010757 × 584 (448 KB)FvasconcellosPyMOL
17:46, 28 August 2007Thumbnail for version as of 17:46, 28 August 20071,000 × 770 (407 KB)Fvasconcellos{{Information |Description=Ribbon diagram of human {{w|thymidylate synthase}} in complex with {{w|deoxyuridine monophosphate}} (orange) and the {{w|enzyme inhibitor}} {{w|raltitrexed}} (lime green).<br>Created using [http://www.accelrys.com/products/downl

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