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Summary
| Description |
English: A model of the signal-transduction pathway during chemotaxis of the sea urchin Arbacia punctulata. Binding of a chemoattractant (ligand) to the receptor — a membrane-bound guanylyl cyclase (GC) — activates the synthesis of cGMP from GTP. Cyclic GMP possibly opens cyclic nucleotide-gated (CNG) K+-selective channels, thereby causing hyperpolarization of the membrane. The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC. On hyperpolarization, hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels allow the influx of Na+ that leads to depolarization and thereby causes a rapid Ca2+ entry through voltage-activated Ca2+ channels (Cav), Ca2+ ions interact by unknown mechanisms with the axoneme of the flagellum and cause an increase of the asymmetry of flagellar beat and eventually a turn or bend in the swimming trajectory. Ca2+ is removed from the flagellum by a Na+/Ca2+ exchange mechanism. [Taken from (Kaupp et al., 2006).] |
| Date | |
| Source | ftp://ftp.weizmann.ac.il/incoming/Fig.1.jpg |
| Author | Prof. Dr. U.B. Kaupp |
| Permission (Reusing this file) |
ftp://ftp.weizmann.ac.il/incoming/License_for_Fig1.pdf |
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Licensing
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
Attribution: Prof. Dr. U.B. Kaupp
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- to share – to copy, distribute and transmit the work
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- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:09, 6 April 2013 | | 2,006 × 772 (498 KB) | Manfre87 | Reverted to version as of 23:08, 25 March 2009 |
| 14:05, 6 April 2013 |  | 2,006 × 772 (245 KB) | Manfre87 | Italian traduction; traduzione in italiano | |
| 23:08, 25 March 2009 |  | 2,006 × 772 (498 KB) | Graeme Bartlett | {{Information |Description={{en|1=Signal transduction in sea-urchin sperm chemotaxis, illustrating a cell membrane with embedded functions}} |Source=ftp://ftp.weizmann.ac.il/incoming/Fig.1.jpg |Author=Prof. Dr. U.B. Kaupp |Date=2006 |Permission=ftp://ftp. |
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