DescriptionRosai-Dorfman Disease in Elderly Female - Aziz Et Al Case Rep Pathol 2012.jpg
English: The image is a composite of cropped excerpts of https://www.hindawi.com/journals/cripa/2012/806130/fig1/ ("Figure 1: Enlarged right cervical lymph node, 2 x 1.5 cm") on the left and https://www.hindawi.com/journals/cripa/2012/806130/fig3/ ("Figure 3: Many large histiocytes with binucleation and emperipolesis, (FNAC, H&E 400)") on the right. The brightness and contrast of the included images were adjusted to best display the macroscopic and microscopic aspects of Rosai-Dorfman disease.
Accompanying text includes: "A 50-year-old Indian female presented with complaints of low grade intermittent fever off and on, weakness, and slowly enlarging painless nodules in the right side of her neck and right groin for the last one and half years. ... Clinical examination revealed average built, mild pallor along with generalized lymphadenopathy involving right cervical (2 x 1.5 cm, multiple, matted) (Figure 1), right axillary (1 x 1 cm), and right inguinal (2 x 2.5 cm) lymph nodes. ... Fine needle aspiration cytology (FNAC) from the enlarged lymph nodes as well as the chest wall lump revealed inflammatory infiltrate consisting of lymphocytes, plasma cells, sparse population of neutrophils along with multiple large histiocytes with abundant eosinophilic cytoplasm and vesicular nuclei, some showing binucleation. Many of these histiocytes showed emperipolesis (i.e., engulfment of intact lymphocytes and plasma cells). No malignant cells or granuloma were seen (Figure 3). These findings were consistent with the diagnosis of Rosai-Dorfman disease."
Date
Source
Aziz M, Ray PS, Haider N, Rathore SP. Diagnosis of Rosai-Dorfman Disease in Elderly Female on Fine Needle Aspiration Cytology: A Case Report. Case Rep Pathol. 2012;2012:806130. doi: 10.1155/2012/806130. At https://www.hindawi.com/journals/cripa/2012/806130/.
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Author
Meher Aziz, Prasenjit Sen Ray, Nazima Haider, and Sumit Prakash Rathore. The authors were with the Department of Pathology, J.N. Medical College, AMU, Aligarh 202002, India.
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