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Summary
| Description |
English: The three core transmembrane proteins in Tight junctions, junctional adhesion molecule (JAM), occludin and claudins seal the hepatocytes. The TJs segregate the membrane of the hepatocytes into basolateral and apical membrane. At the basolateral (sinusoidal) membrane: ABCA1, ABCC1 (MRP1), ABCC3 (MRP3) and ABCC6 (MRP6) are expressed. At the apical (canalicular) membrane: ABCB1(MDR1), ABCB4 (MDR3), ABCB11 (BSEP), ABCC2 (MRP2), ABCC4 (MRP4, which localisation in hepatocytes is controversial), ABCG2 (BCRP) and ABCG5/G8 are expressed. (Tight junctions; TJs, ATP-binding cassette; ABC, multidrug resistance-associated protein; MRP, multidrug resistance; MDR, bile salt export pump; BSEP, breast cancer resistance protein; BCRP) English: Membrane proteins of the polarized hepatocytes |
| Date | |
| Source | Own work |
| Author | Erdélyi-Belle Boglárka PhD |
It was a figure in the introduction chapter of my PhD thesis
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:50, 12 November 2015 | | 1,039 × 730 (567 KB) | Erdélyi-Belle Boglárka PhD | User created page with UploadWizard |
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