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Summary
| Description |
English: Iron crosses the blood–brain barrier (BBB) either by:
• The transcytosis pathway, where the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” undergoes endocytosis and exocytosis from the luminal pole to the cerebral extracellular matrix (ECM) and interstitial fluid. • The facilitated transporter pathway, where endothelial cells internalize the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” in endosome, reduce ferric Fe3+ ion to ferrous Fe2+ ion by STEAP3 enzyme and then Fe2+ ion crosses the endosomal membrane thanks to DMT1. Fer²+ is then exported to the extracellular matrix (ECM) and interstitial fluid, via ferroportin coupled with ceruloplasmin (Note that transferrin is not only a plasmatic protein and choroid plexuses can secrete it). |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ |
| Author | Christian Berthou, Jean Paul Iliou, and Denis Barba |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:37, 30 January 2024 | | 700 × 923 (165 KB) | PecMo | Uploaded a work by Christian Berthou, Jean Paul Iliou, and Denis Barba from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ with UploadWizard |
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