DescriptionHistopathology of invasive low-grade serous carcinoma of ovary.png
English: Histopathology of invasive low-grade serous carcinoma of ovary with typical features. H&E stain. The left image shows lower magnification, including inverted macropapillae which are with broad fibrovascular cores surrounded by clear (white) clefts. Invasion (characterized by small irregular nests to single cells) should be over 5 mm in size to distinguish it from a borderline serous tumor. Calcifications often form psammoma bodies. Right picture shows higher magnification, including hobnailing which is individual cells protruding into the lumen of glands. Cells may have up to moderate atypia: They may have conspicuous nucleoli, and up to 3x variation in nuclear sizes compared to each other. More atypical features indicate a high-grade serous carcinoma.
Reference for findings: Erna Forgó, M.D., Teri A. Longacre, M.D.. Low grade serous carcinoma. Pathology Outlines. Last staff update: 23 July 2020
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Captions
Histopathology of invasive low-grade serous carcinoma of ovary, H&E stain