File:A conserved apoptotic pathway in nematodes, mammals and fruitflies.jpg

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Description	Functional homologues of caspases and caspase regulators across species are indicated by the same colour. Caspase-9 in mammals and Dronc in the fruitfly Drosophila melanogaster are initiator caspases, whereas caspase-3 and -7 in mammals and Drice in fruitflies belong to the class of effector caspases. CED-3 (cell-death abnormality-3) in the nematode worm Caenorhabditis elegans functions both as an initiator and effector caspase. The inhibitor of apoptosis (IAP)proteins suppress apoptosis by negatively regulating the caspases, whereas SMAC (second mitochondria-derived activator of caspases)/DIABLO (direct IAP-binding protein with low pI) in mammals and the RHG proteins Reaper, Hid, Grim and Sickle in fruitflies can remove the IAP-mediated negative regulation of caspases. AIF, apoptosis-inducing factor; APAF1, apoptotic-protease-activating factor-1; Cyt c, cytochrome c; EndoG, endonuclease G; HTRA2, high-temperature-requirement protein A2
Author or copyright owner	Stefan J. Riedl and Yigong Shi
Source (WP:NFCC#4)	Nature Reviews Molecular Cell Biology 5, 897-907 (November 2004) \| doi:10.1038/nrm1496
Date of publication	November 2004
Use in article (WP:NFCC#7)	Programmed cell death
Purpose of use in article (WP:NFCC#8)	This image shows the differences and similarities of programmed cell death in three different model organisms: Nematodes, mammals and fruitflies.
Not replaceable with free media because (WP:NFCC#1)	n.a.
Not replaceable with textual coverage because (WP:NFCC#1)	This can be a complicated topic and the illustration is a simple way to illustrate it.
Minimal use (WP:NFCC#3)	There is only 1 image on this page and there is no image depicting this.
Respect for commercial opportunities (WP:NFCC#2)	n.a.
Fair useFair use of copyrighted material in the context of Programmed cell death//en.wiki.x.io/wiki/File:A_conserved_apoptotic_pathway_in_nematodes,_mammals_and_fruitflies.jpgtrue

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	17:22, 15 February 2017		365 × 273 (11 KB)	DatBot (talk \| contribs)	Reduce size of non-free image (BOT - disable)
	20:28, 28 February 2014	No thumbnail	800 × 600 (41 KB)	Zbalmuth (talk \| contribs)	Uploading an excerpt from a non-free work using File Upload Wizard

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Programmed cell death