Fer-de-Lance is French for spearhead (literally "iron of the lance"), and may refer to:
Snakes of the genus Bothrops, especially:
- B. lanceolatus, the Martinique lancehead snake
- B. caribbaeus, the Saint Lucia lancehead
- B. atrox, the common lancehead, native to tropical South America east of the Andes and to Trinidad
- B. asper, the terciopelo or Central American lancehead, native to Central and northwestern South America
- B. insularis, the golden lancehead, a critically endangered Brazilian species
Other:
- Fer-de-Lance (novel), a 1934 Nero Wolfe series novel by Rex Stout
- Fer-de-Lance (comics), Teresa Vasquez, a Marvel comics super-villain
- Fer-de-Lance (film) a 1974 film starring David Janssen