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Erica Ollmann Saphire

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Erica Ollmann Saphire is an American structural biologist and immunologist and a professor at the La Jolla Institute for Immunology. She investigates the structural biology of viruses that cause hemorrhagic fever such as Ebola, Sudan, Marburg, Bundibugyo, and Lassa.

Erica Ollmann Saphire, President and CEO of La Jolla Institute for Immunology, 2021

Saphire has served as president and CEO of La Jolla Institute for Immunology since 2021.[1]

Early life and education

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Saphire earned a Bachelor of Arts in biochemistry and cell biology from Rice University in 1993. She then moved to Scripps Research, where she earned a PhD in molecular biology in 2000.[2] Her doctoral research focused on the crystal structure of a neutralizing antibody against HIV-1.[3] She was an avid rugby player throughout college and graduate school, and toured twice with the United States women's national rugby union team.[4]

Career and research

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After an immunology postdoctoral fellowship at Scripps Research, Saphire joined the faculty in the department of immunology as an assistant professor in 2003. She was promoted to associate professor in 2008 and full professor in 2012.[2] In 2019, joined the faculty at the La Jolla Institute for Immunology.[5]

Saphire solved the first structure of the entire human IgG.[6] The hexameric array predicted the assembly by which IgG could recruit C1q and launch the complement cascade,[7] which Saphire confirmed by obtaining the cryoEM structure of the C1q-IgG complex and hexameric IgG preparations.

Saphire is best known for her research on Ebola virus and other causes of viral hemorrhagic fever.[5] She was the first to discover the structure of the Ebola virus surface glycoprotein[8] and predicted that the Ebola virus receptor was located in the endosome rather than on the cell surface. Later, she showed that the Ebola virus VP40 matrix protein can fold into multiple distinct structures.[3] In 2024, Saphire used in situ cryo-electron tomography to illuminate Ebola virus replication factories inside living cells revealing a hitherto unresolved third and outer layer of the nucleoprotein.[9] Her laboratory has also discovered the structure of the glycoproteins of Sudan virus, Marburg virus, Bundibugyo virus, Lassa virus and LCMV.[10] On field work in West Africa, she followed rodents to study how they spread viruses such as Ebola and Lassa.[5] Saphire attracted national media attention in 2014 when she launched a crowdfunding appeal to raise funds for equipment to assist in research to fight Ebola virus.[5][11]

In recent work, Saphire determined the cryo-electron microscopy structure of the measles virus fusion protein in complex with an antibody and determined that the antibody can trap the fusion protein in an intermediate state, thus halting fusion.[12]

Saphire directs the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC)[10] and is a strong advocate for strategic collaborations to rapidly develop treatments for Ebola and other severe threats.[13] In 2020, Saphire was named director of the Coronavirus Immunotherapy Consortium (CoVIC), an international effort to evaluate human antibodies against the novel coronavirus, SARS-CoV-2.[14][15] Her lab also co-led research into COVID-19 mutations with scientists at the Los Alamos National Laboratory.[16] Saphire is also spearheading "America's SHIELD:Strategic Herpesvirus Immune Evasion and Latency Defense"[17] as part of ARPA-H's Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx) program.

In 2021, Saphire was appointed president and CEO of La Jolla Institute for Immunology. She succeeded Dr. Mitchell Kronenberg, who had served as institute president since 2003. Saphire is the institute's fifth president and is the first woman to serve in that role.[1]

Awards

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Saphire received the Presidential Early Career Award for Scientists and Engineers and the Global Virus Network's Gallo Award for Scientific Excellence and Leadership.[10] She received the American Society for Biochemistry and Molecular Biology's Young Investigator Award in 2015,[3] the Pantheon Award for Academia, Non-Profit, & Research in 2023,[18] the Marion Spencer Fay Award in 2023[19] and the Bert & Natalie Vallee Award in Biomedical Science (2023).[20]

References

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  1. ^ a b "Erica Ollmann Saphire appointed president and CEO of La Jolla Institute for Immunology". lji.org. La Jolla Institute for Immunology. Retrieved March 25, 2024.
  2. ^ a b "Erica Ollmann Saphire, PhD". Scripps Research. Retrieved October 6, 2019.
  3. ^ a b c Kuo, Maggie (March 2015). "Saphire, a 'leading light in molecular biology and human health'". American Society for Biochemistry and Molecular Biology. Archived from the original on October 6, 2019. Retrieved October 6, 2019.
  4. ^ Robbins, Gary (September 21, 2011). "A Scientist's life: 10 Things Erica Ollmann Saphire Has Done". San Diego Union-Tribune. Retrieved October 6, 2019.
  5. ^ a b c d Robbins, Gary (February 27, 2019). "Renowned virus fighter Erica Ollmann Saphire leaves Scripps Research for a competitor". San Diego Union-Tribune. Retrieved October 6, 2019.
  6. ^ Saphire, Erica Ollmann; Parren, Paul W. H. I.; Pantophlet, Ralph; Zwick, Michael B.; Morris, Garrett M.; Rudd, Pauline M.; Dwek, Raymond A.; Stanfield, Robyn L.; Burton, Dennis R.; Wilson, Ian A. (August 10, 2001). "Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design". Science. 293 (5532): 1155–1159. doi:10.1126/science.1061692. ISSN 0036-8075. PMID 11498595.
  7. ^ Diebolder, Christoph A.; Beurskens, Frank J.; de Jong, Rob N.; Koning, Roman I.; Strumane, Kristin; Lindorfer, Margaret A.; Voorhorst, Marleen; Ugurlar, Deniz; Rosati, Sara; Heck, Albert J. R.; van de Winkel, Jan G. J.; Wilson, Ian A.; Koster, Abraham J.; Taylor, Ronald P.; Ollmann Saphire, Erica (March 14, 2014). "Complement Is Activated by IgG Hexamers Assembled at the Cell Surface". Science. 343 (6176): 1260–1263. Bibcode:2014Sci...343.1260D. doi:10.1126/science.1248943. ISSN 0036-8075. PMC 4250092. PMID 24626930.
  8. ^ Lee, Jeffrey E.; Fusco, Marnie L.; Hessell, Ann J.; Oswald, Wendelien B.; Burton, Dennis R.; Saphire, Erica Ollmann (July 2008). "Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor". Nature. 454 (7201): 177–182. Bibcode:2008Natur.454..177L. doi:10.1038/nature07082. ISSN 1476-4687. PMC 2700032. PMID 18615077.
  9. ^ "Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography". Cell.
  10. ^ a b c "Leading Structural Immunologist Erica Ollmann Saphire will join La Jolla Institute for Immunology". La Jolla Institute for Immunology. February 25, 2019. Retrieved October 6, 2019.
  11. ^ Perry, Tony (October 12, 2014). "Ebola researcher turns to crowdfunding for help in finding cure". Los Angeles Times. Retrieved October 6, 2019.
  12. ^ Zyla, Dawid S.; Della Marca, Roberta; Niemeyer, Gele; Zipursky, Gillian; Stearns, Kyle; Leedale, Cameron; Sobolik, Elizabeth B.; Callaway, Heather M.; Hariharan, Chitra; Peng, Weiwei; Parekh, Diptiben; Marcink, Tara C.; Diaz Avalos, Ruben; Horvat, Branka; Mathieu, Cyrille (June 28, 2024). "A neutralizing antibody prevents postfusion transition of measles virus fusion protein". Science. 384 (6703): eadm8693. doi:10.1126/science.adm8693. ISSN 0036-8075. PMID 38935733.
  13. ^ Saphire, Erica Ollmann; Dye, John M.; Kobinger, Gary P.; Zeitlin, Larry; Chandran, Kartik; Garry, Robert F. (2017). "How to turn competitors into collaborators". Nature. 541 (7637): 283–285. Bibcode:2017Natur.541..283S. doi:10.1038/541283a. PMID 28102273.
  14. ^ Mento, Tarryn (April 11, 2020). "La Jolla Institute Leading Global Hunt For Antibodies To Coronavirus". KPBS Public Media. Retrieved April 23, 2021.
  15. ^ "La Jolla Institute Gets $1M Gift for COVID Research". San Diego Business Journal. August 5, 2020. Retrieved April 23, 2021.
  16. ^ Korber, Bette; Fischer, Will M.; Gnanakaran, Sandrasegaram; Yoon, Hyejin; Theiler, James; Abfalterer, Werner; Hengartner, Nick; Giorgi, Elena E.; Bhattacharya, Tanmoy; Foley, Brian; Hastie, Kathryn M. (August 20, 2020). "Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus". Cell. 182 (4): 812–827.e19. doi:10.1016/j.cell.2020.06.043. ISSN 0092-8674. PMC 7332439. PMID 32697968.
  17. ^ "The SHIELD: La Jolla Institute for Immunology Gets $49M to Drug Herpesviruses". September 26, 2024.
  18. ^ "California Life Sciences announces 20th annual Pantheon Award winners".
  19. ^ "Past Marion Spencer Fay Award Honorees". February 2, 2024.
  20. ^ "Erica Ollmann Saphire to receive ASBMB's 2023 Bert & Natalie Vallee Award in Biomedical Science".
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