Dennis J. Selkoe (born 25 September 1943) is an American physician (neurologist) known for his research into the molecular basis of Alzheimer's disease.[1] In 1985 he became Co-Director of the Center for Neurological Diseases and from 1990, Vincent and Stella Coates Professor of Neurological Diseases at Harvard Medical School.[2] He is also a Fellow of the AAAS and a member of the National Academy of Medicine.[3]
Dennis J. Selkoe | |
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Born | |
Alma mater |
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Known for |
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Spouse | Polly Selkoe |
Children | 2 including Greg Selkoe |
Awards | |
Scientific career | |
Fields | Medicine, Neurology |
Career and early life
editSelkoe studied at Columbia University (Bachelor's degree 1965) and the University of Virginia School of Medicine (M. D. 1969).[4] He took up a residency at the University of Pennsylvania Hospital (1969). From 1970 to 1972, he performed research at the National Institutes of Health and continued his residency as a neurologist at the Peter Bent Brigham Children's Hospital and Beth Israel Hospital in Boston.
In 1975, he held the position of instructor at the Brigham and Women's Hospital in Boston, before moving up to assistant professor in 1978.[5]
In 1978, he established a laboratory at Brigham and Women's to apply biochemical and cell biological methods to the study of degenerative neural diseases such as Alzheimer's and Parkinson's disease.[6]
In 1982, he and collaborators isolated the clusters of neurofibrils typical of Alzheimer's disease and described their chemical properties. With other laboratories, he showed that the tau protein of the microfibrils is their main component. With his laboratory, he also conducted extensive research on the second pathogenic component, senile plaques of beta-amyloid (Aβ).[7] They discovered in 1992 that Aβ is also formed in normal cells from its precursor amyloid precursor protein. The study of these processes led to the identification of inhibitors for the formation of Aβ. Selkoe was also able to show with his laboratory that innate mutations in the APP genes and the presenilin genes cause Alzheimer's disease (increased Aβ production). In 1999, he and co-workers identified presenilin as a component of the long-sought-after gamma-secretase, one of the enzymes involved in the pathogenic conversion of APP to Aβ in Alzheimer's disease. In his laboratory, it could also be shown that small, soluble oligomers from Aβ can damage the synapses and have an influence on memory performance.
He was the principal founding scientist of the pharmaceutical company Athena Neurosciences (later Elan Corporation).[8] In 2001 he was one of the founders of the Harvard Medical Center for Neurodegeneration and Repair.[9] He has been on the board of Prothena Corporation since 2013.[10]
He has an h-index of 183 according to Semantic Scholar.[11]
Awards and honors
edit- Life Achievement Award from the Alzheimer's Association (2008)[12]
- Member of the National Academy of Medicine (2005)
- Fellow of the American Association for the Advancement of Science (2003)
- Dr A. H. Heineken Prize for Medicine (2002)[13]
- Rita Hayworth Award from the Alzheimer's Association (1995)[14]
- Honorary doctorate from Harvard University (1991)
- Potamkin Prize (1989)
- Metlife Foundation Award for Medical Research in Alzheimer's Disease (1986)
- Wood Kalb Foundation Prize (1984)
Publications
editAuthored
edit- Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders (2003)
- The therapeutics of Alzheimer's disease: Where we stand and where we are heading (2013)
- SnapShot: Pathobiology of Alzheimer's Disease (2013)
- Preventing Alzheimer’s Disease' (2012)
- Resolving controversies on the path to Alzheimer's therapeutics (2011)
- Alzheimer's disease (2011)
- Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease (2008)
- Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior (2008)
- Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease (2007)
- Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise (2006)
- The ups and downs of Abeta (2006)
Co-authored
edit- A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice (with Silke Nuber, Alice Y. Nam, Molly M. Rajsombath, Haley Cirka Xiaoping Hronowski, Junmin Wang, Kevin Hodgetts, Liubov S. Kalinichenko, Christian P. Müller, Vera Lambrecht, Jürgen Winkler, Andreas Weihofen, Thibaut Imberdis, Ulf Dettmer, Saranna Fanning (2020)
- Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies (with John B Sanderson, Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini, Aurelia Hays Watson, Laura De Boni, Valentina N Lagomarsino, Tracy L Young-Pearse, Xinyue Liu, Thomas C Pochapsky, Bradley T Hyman, Dennis W Dickson, David Klenerman, Dennis J Selkoe, Tim Bartels) (2020)
- Amyloid β-protein and beyond: the path forward in Alzheimer's disease (with Walsh DM) (2020)
- Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase (with Mengel D, Liu W, Glynn RJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. ) (2020)
References
edit- ^ "Dr. Dennis J. Selkoe Neurologist in Boston, MA". U.S. News & World Report. Retrieved 2020-12-03.
- ^ "DENNIS SELKOE, M.D." Cure Alzheimer's Fund. Curealz. 2010-05-30. Retrieved 2020-12-03.
- ^ "Institute of Medicine News: IOM elects 64 new members, five foreign associates". American Association for the Advancement of Science. Christine Stencel. 2005-10-24. Retrieved 2020-12-07.
- ^ "Biography – The Laboratory of Dennis J. Selkoe, MD". Brigham and Women's Hospital. Selkoe Laboratory. Retrieved 2020-12-03.
- ^ "ADDING MULTIMEDIA MetLife Foundation Marks 20th Anniversary of Awards for Medical Research in Alzheimer's Disease; Two Decades of Investing in Science and Scientists". Business Wire. 2006-02-14. Retrieved 2020-12-07.
- ^ "The Laboratory of Dennis J. Selkoe, MD". Brigham and Women's Hospital. Selkoe Laboratory. Retrieved 2020-12-03.
- ^ "The Laboratory of Dennis J. Selkoe, MD". Selkoe Lab. Retrieved 2020-12-07.
- ^ "Dennis Selkoe, MD". World Neuroscience Innovation Forum. 2017-03-27. Archived from the original on October 1, 2020. Retrieved 2020-12-07.
{{cite web}}
: CS1 maint: unfit URL (link) - ^ "Biography". Selkoe Lab. Retrieved 2020-12-07.
- ^ "Dennis J. Selkoe, M.D." Prothena Corporation plc. Retrieved 26 August 2021.
- ^ "D. Selkoe". Semantic Scholar. Retrieved 14 November 2022.
- ^ "AAIC 2019 - Awards". Alzheimer's Association. AAIC. 2019. Retrieved 2020-12-03.
- ^ "DENNIS J. SELKOE (1943), USA". Royal Netherlands Academy of Arts and Sciences. KNAW. Archived from the original on 2020-09-28.
- ^ "Rochester neuroscientist receives $1 million Alzheimer's research award". American Association for the Advancement of Science. Tom Rickey. 1999-11-16. Retrieved 2020-12-03.