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Corinna S. Schindler

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Corinna S. Schindler is a Professor of Chemistry at the University of Michigan.[1] She develops catalytic reactions with environmentally benign metals such as iron, towards the synthesis of biologically active small molecules. For her research in the development of new catalysts, Schindler has been honored with several early-career researcher awards including the David and Lucile Packard Foundation Fellowship in 2016,[2] the Alfred P. Sloan Fellowship in 2017,[3] and being named a member of the C&EN Talented 12 in 2017.[4] Schindler has served on the Editorial Board of Organic and Bimolecular Chemistry since 2018.[5]

Corianna S. Schindler
Alma materTechnical University of Munich Diploma 2004
ETH Zurich PhD 2010
Scientific career
InstitutionsUniversity of Michigan (2013–present)
Scripps Research
Doctoral advisorErick M. Carreira
Other academic advisorsK.C. Nicolaou, Eric N. Jacobsen
Websiteschindlerresearchgroup.com

Early life and education

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Schindler was born and raised in Schwäbisch Hall, Germany. She did her undergraduate work at the Technical University of Munich, where she worked on organometallic chemistry.[6] She completed her Diploma Thesis (equivalent of a Master of Science) in 2004 under the direction of K. C. Nicolaou at the Scripps Research Institute in La Jolla, California. In Nicolaou's group, Schindler worked on the total synthesis of the natural products marinomycins A-C.[7][8]

Schindler earned her doctorate degree in 2010 at the ETH Zurich under the direction of Erick M. Carreira. Her PhD thesis focused on the development of new synthetic strategies to access the aeruginosin class of natural products,[9][10] centered on the opening of oxabicyclic ring systems.[11]

After completing her doctorate degree, Schindler joined Eric N. Jacobsen's research group at Harvard University as a Feodor Lynen Postdoctoral Fellow.[12] In Jacobsen's group, she developed enantioselective aza-Sakurai reactions[13] and photoredox catalysis for amine oxidations.[14]

Schindler began her independent career in 2013 at the University of Michigan as an Assistant Professor. She was promoted to Associate Professor (and granted tenure) in 2019.[6]

Research interests

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Schindler's research group includes an international team of researchers working in the area of organic chemistry with an emphasis on the synthesis of molecules of biological importance.  Key areas of interest include the development of new synthetic routes for molecules that are potentially important in the areas of material science and medicine. Schindler's research group also focuses on the synthesis of biologically active natural products such as the platelet aggregation and influenza virus replication inhibiting herqulines B and C.[15][16]

Her laboratory recently reported a carbonyl-olefin ring closure metathesis reaction using an environmentally benign iron catalyst, iron(III) chloride, that could replace widely-used precious metal catalysts, which are expensive and can be harmful to the environment.[17][18]

Awards and honors

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For her contributions to science, Schindler has been the recipient of many research and recognition awards.[12]  These include:

Publications

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  • Schindler, Corinna S.; Forster, Patrik M.; Carreira, Erick M. (13 August 2010). "Facile Formation of N-Acyl-oxazolidinone Derivatives Using Acid Fluorides". Organic Letters. 12 (18). American Chemical Society (ACS): 4102–4105. doi:10.1021/ol1016977. ISSN 1523-7060. PMID 20707372.
  • Schindler, Corinna S.; Diethelm, Stefan; Carreira, Erick M. (15 July 2009). "Nucleophilic Opening of Oxabicyclic Ring Systems". Angewandte Chemie International Edition. 48 (34). Wiley: 6296–6299. doi:10.1002/anie.200902046. ISSN 1433-7851. PMID 19606434.
  • Schindler, Corinna S.; Carreira, Erick M. (2009). "Rapid formation of complexity in the total synthesis of natural products enabled by oxabicyclo[2.2.1]heptene building blocks". Chemical Society Reviews. 38 (11). Royal Society of Chemistry (RSC): 3222–3241. doi:10.1039/b915448p. ISSN 0306-0012. PMID 19847353.
  • Schindler, Corinna S.; Stephenson, Corey R. J.; Carreira, Erick M. (3 November 2008). "Enantioselective Synthesis of the Core of Banyaside, Suomilide, and Spumigin HKVV". Angewandte Chemie International Edition. 47 (46). Wiley: 8852–8855. doi:10.1002/anie.200803655. ISSN 1433-7851. PMID 18855958.
  • Schindler, Corinna S.; Jacobsen, Eric N. (31 May 2013). "A New Twist on Cooperative Catalysis". Science. 340 (6136). American Association for the Advancement of Science (AAAS): 1052–1053. Bibcode:2013Sci...340.1052S. doi:10.1126/science.1238769. ISSN 0036-8075. PMID 23723222. S2CID 35756570.
  • Schindler, Corinna S.; Bertschi, Louis; Carreira, Erick M. (22 October 2010). "Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site". Angewandte Chemie International Edition. 49 (48). Wiley: 9229–9232. doi:10.1002/anie.201004047. ISSN 1433-7851. PMID 20967913.

References

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  1. ^ "Corinna Schindler | U-M LSA Chemistry". lsa.umich.edu. Retrieved 2021-05-31.
  2. ^ "Schindler, Corinna S." The David and Lucile Packard Foundation. Retrieved 2021-05-31.
  3. ^ "Seven U-M scientists selected for Sloan Fellowships". University of Michigan News. 2017-02-21. Retrieved 2021-05-31.
  4. ^ "Corinna Schindler – Talented 12". 2020-10-01. Archived from the original on 2020-10-01. Retrieved 2021-05-31.
  5. ^ says, FPSJOB com. "OBC welcomes new Editorial Board member Corinna S. Schindler – Organic & Biomolecular Chemistry Blog". Retrieved 2021-05-31.
  6. ^ a b "Corinna Schindler". Schindler Group. Retrieved 2021-05-31.
  7. ^ Nicolaou, K. C.; Nold, Andrea L.; Milburn, Robert R.; Schindler, Corinna S. (2006). "Total Synthesis of Marinomycins A–C". Angewandte Chemie International Edition. 45 (39): 6527–6532. doi:10.1002/anie.200601867. ISSN 1521-3773. PMID 16977657.
  8. ^ Nicolaou, K. C.; Nold, Andrea L.; Milburn, Robert R.; Schindler, Corinna S.; Cole, Kevin P.; Yamaguchi, Junichiro (2007-02-01). "Total Synthesis of Marinomycins A−C and of Their Monomeric Counterparts Monomarinomycin A and iso-Monomarinomycin A". Journal of the American Chemical Society. 129 (6): 1760–1768. doi:10.1021/ja068053p. ISSN 0002-7863. PMID 17249678.
  9. ^ Schindler, Corinna S.; Stephenson, Corey R. J.; Carreira, Erick M. (2008). "Enantioselective Synthesis of the Core of Banyaside, Suomilide, and Spumigin HKVV". Angewandte Chemie International Edition. 47 (46): 8852–8855. doi:10.1002/anie.200803655. ISSN 1521-3773. PMID 18855958.
  10. ^ Schindler, Corinna S.; Bertschi, Louis; Carreira, Erick M. (2010). "Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site". Angewandte Chemie International Edition. 49 (48): 9229–9232. doi:10.1002/anie.201004047. ISSN 1521-3773. PMID 20967913.
  11. ^ Schindler, Corinna S.; Diethelm, Stefan; Carreira, Erick M. (2009). "Nucleophilic Opening of Oxabicyclic Ring Systems". Angewandte Chemie International Edition. 48 (34): 6296–6299. doi:10.1002/anie.200902046. ISSN 1521-3773. PMID 19606434.
  12. ^ a b "Corinna Schindler of Chemistry Awarded Packard Fellowship | U-M LSA U-M College of LSA". lsa.umich.edu.
  13. ^ Park, Yongho; Schindler, Corinna S.; Jacobsen, Eric N. (2016-11-16). "Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-Bond Donor and Lewis Base". Journal of the American Chemical Society. 138 (45): 14848–14851. doi:10.1021/jacs.6b09736. ISSN 0002-7863. PMC 5148636. PMID 27787993.
  14. ^ Bergonzini, Giulia; Schindler, Corinna S.; Wallentin, Carl-Johan; Jacobsen, Eric N.; Stephenson, Corey R. J. (2013-11-26). "Photoredox activation and anion binding catalysis in the dual catalytic enantioselective synthesis of β-amino esters". Chemical Science. 5 (1): 112–116. doi:10.1039/C3SC52265B. ISSN 2041-6539. PMC 3842187. PMID 24294480.
  15. ^ Zhu, Xu; McAtee, Christopher C.; Schindler, Corinna S. (2019-02-14). "Total Syntheses of Herqulines B and C". Journal of the American Chemical Society. 141 (8): 3409–3413. doi:10.1021/jacs.8b13849. ISSN 0002-7863. PMID 30762360. S2CID 73455728.
  16. ^ "Total Syntheses of Herqulines B and C - SYNFORM - Thieme Chemistry". Thieme. Retrieved 2021-05-31.
  17. ^ Ludwig, Jacob R.; Zimmerman, Paul M.; Gianino, Joseph B.; Schindler, Corinna S. (2016). "Iron( III )-catalysed carbonyl–olefin metathesis". Nature. 533 (7603): 374–379. Bibcode:2016Natur.533..374L. doi:10.1038/nature17432. ISSN 1476-4687. PMID 27120158. S2CID 205248433.
  18. ^ McAtee, Christopher C.; Riehl, Paul S.; Schindler, Corinna S. (2017-03-01). "Polycyclic Aromatic Hydrocarbons via Iron(III)-Catalyzed Carbonyl–Olefin Metathesis". Journal of the American Chemical Society. 139 (8): 2960–2963. doi:10.1021/jacs.7b01114. ISSN 0002-7863. PMC 6095473. PMID 28221039.
  19. ^ "ACS Award in Pure Chemistry". ACS. Retrieved 2 September 2020.
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