LILRB3

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

LILRB3
Identifiers
Aliases	LILRB3, CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB, PIR-B, leukocyte immunoglobulin like receptor B3
External IDs	OMIM: 604820; MGI: 1195974; HomoloGene: 134028; GeneCards: LILRB3; OMA:LILRB3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 54,216,278 bp End 54,223,506 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte monocyte spleen upper lobe of left lung appendix right lung bone marrow bone marrow cells right coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity amyloid-beta binding signaling receptor activity Cellular component membrane integral component of membrane integral component of plasma membrane plasma membrane secretory granule membrane Biological process immune system process adaptive immune response defense response cell surface receptor signaling pathway negative regulation of osteoclast differentiation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11025 18729 Ensembl ENSG00000275019 ENSG00000274587 ENSG00000277816 ENSG00000204577 n/a UniProt Q6PI73 O75022 n/a RefSeq (mRNA) NM_001081450 NM_006864 NM_001320960 NM_001289428 NM_008848 NM_011093 RefSeq (protein) XP_006726238.1 XP_006726376 XP_006726377 XP_011546876 XP_011546877 n/a Location (UCSC) Chr 19: 54.22 – 54.22 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

See also

• Cluster of differentiation

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Sloane DE, Tedla N, Awoniyi M, et al. (2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition". Blood. 104 (9): 2832–9. doi:10.1182/blood-2004-01-0268. PMID 15242876.
• Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
• Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J. Immunol. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cella M, Döhring C, Samaridis J, et al. (1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J. Exp. Med. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
• Samaridis J, Colonna M (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur. J. Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• LILRB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.