IGSF8

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. IGSF8 has also been designated as CD316 (cluster of differentiation 316).

IGSF8
Identifiers
Aliases	IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.2 Start 160,091,340 bp End 160,098,943 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.59 cM Start 172,089,208 bp End 172,147,408 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbens Top expressed in ventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component extracellular exosome membrane integral component of membrane plasma membrane Biological process skeletal muscle tissue development nervous system development cell population proliferation single fertilization cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93185 140559 Ensembl ENSG00000162729 ENSMUSG00000038034 UniProt Q969P0 Q8R366 RefSeq (mRNA) NM_001206665 NM_052868 NM_001320247 NM_080419 RefSeq (protein) NP_001193594 NP_001307176 NP_443100 NP_536344 Location (UCSC) Chr 1: 160.09 – 160.1 Mb Chr 1: 172.09 – 172.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells". Biochem. J. 373 (Pt 2): 409–21. doi:10.1042/BJ20030343. PMC 1223506. PMID 12708969.
• Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res. 63 (10): 2665–74. PMID 12750295.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
• Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. Cell Biol. 163 (5): 1167–77. doi:10.1083/jcb.200309113. PMC 2173626. PMID 14662754.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013–9. doi:10.1182/blood-2003-07-2201. PMID 15070678.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.
• Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–75. doi:10.1074/jbc.M602116200. PMID 16690612.
• Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells". Mol. Cell. Biol. 27 (21): 7718–26. doi:10.1128/MCB.00180-07. PMC 2169036. PMID 17785435.

External links

• IGSF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)