Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene .[ 5] [ 6]
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids . GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000135454 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006731 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagata Y, Yamashiro S, Yodoi J, Lloyd KO, Shiku H, Furukawa K (Jul 1992). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides" . J Biol Chem . 267 (17): 12082–9. doi :10.1016/S0021-9258(19)49809-8 PMID 1601877 . ^ a b "Entrez Gene: B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1" .
Nagata Y, Yamashiro S, Yodoi J, et al. (1994). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides" . J. Biol. Chem . 269 (9): 7045. doi :10.1016/S0021-9258(17)37480-X PMID 8120069 . Meurer JA, Naylor JM, Baker CA, et al. (1996). "cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase". J. Biochem . 118 (3): 568–74. doi :10.1093/oxfordjournals.jbchem.a124947 . PMID 8690719 . Furukawa K, Soejima H, Niikawa N, Shiku H (1996). "Genomic organization and chromosomal assignment of the human beta1, 4-N-acetylgalactosaminyltransferase gene. Identification of multiple transcription units" . J. Biol. Chem . 271 (34): 20836–44. doi :10.1074/jbc.271.34.20836 PMID 8702839 . Jaskiewicz E, Zhu G, Bassi R, et al. (1996). "Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease" . J. Biol. Chem . 271 (42): 26395–403. doi :10.1074/jbc.271.42.26395 PMID 8824296 . Giraudo CG, Rosales Fritz VM, Maccioni HJ (1999). "GA2/GM2/GD2 synthase localizes to the trans-golgi network of CHO-K1 cells" . Biochem. J . 342. Pt 3 (3): 633–40. doi :10.1042/bj3420633 . PMC 1220504 PMID 10477274 . Toba S, Tenno M, Konishi M, et al. (2000). "Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9)". Biochim. Biophys. Acta . 1493 (1–2): 264–8. doi :10.1016/S0167-4781(00)00180-9 . PMID 10978536 . Li J, Yen TY, Allende ML, et al. (2001). "Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains" . J. Biol. Chem . 275 (52): 41476–86. doi :10.1074/jbc.M007480200 PMID 11018043 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR". Mol. Cell. Biochem . 298 (1–2): 59–68. doi :10.1007/s11010-006-9350-0 . hdl :11383/1672116 PMID 17119850 . S2CID 29889795 .
